Inhibitory Effect of NMDA on Dopaminergic Transmission in a Slice Preparation of Rat Globus Pallidus

Tomomi Shindou, Tomomi Shindou, Shuichi Koizumi, Yasufumi Kataoka, Kenji Yamamoto, Hiroshi Nakanishi

研究成果: ジャーナルへの寄稿学術誌査読

4 被引用数 (Scopus)

抄録

The effect of N-mcthyl-D-aspartate (NMDA) on KCl-evoked endogenous dopamine (DA) release from slices of rat globus pallidus (GP) was examined. NMDA inhibited the KCl-evoked DA release in a dose-dependent manner. This inhibition was blocked by CPP, an NMDA antagonist. Tetrodotoxin partially antagonized the effect of NMDA. The NMDA-induced inhibition was also partially antagonized by bicuculline methiodide and was mimicked by muscimol. These results strongly suggest that 1) an activation of NMDA receptors exerts an inhibitory effect on dopaminergic transmission in GP and 2) GABAergic transmission is involved in the effect of NMDA.

本文言語英語
ページ(範囲)79-82
ページ数4
ジャーナルthe japanese journal of pharmacology
58
1
DOI
出版ステータス出版済み - 1月 1992

!!!All Science Journal Classification (ASJC) codes

  • 薬理学

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