Inhibitory effect of norditerpenes on LPS-induced TNF-α production from the Okinawan soft coral, Sinularia sp.

Hiroko Takaki, Ryoji Koganemaru, You Iwakawa, Ryuichi Higuchi, Tomofumi Miyamoto

研究成果: ジャーナルへの寄稿学術誌査読

35 被引用数 (Scopus)

抄録

An ethanol (EtOH) extract of the soft coral (Sinularia sp.), collected in Okinawa, demonstrated a potent inhibitory effect on lipopolysaccharide (LPS)-induced tumor necrosis factor-α (TNF-α) production by murine macrophage-like cells (RAW264.7). The activity-guided purification of the EtOH extract resulted in the isolation of two norditerpenes, norcembrenolide (1) and sinuleptolide (2). These structures were identified from the spectroscopic data. Norcembrenolide (1) and sinuleptolide (2) inhibited TNF-α production in a dose-dependent manner, and showed a more potent effect than prednisolone at the concentration of 33 μg/ml. They also exhibited an inhibitory effect on nitric oxide (NO) production not influenced by cytotoxicity.

本文言語英語
ページ(範囲)380-382
ページ数3
ジャーナルBiological and Pharmaceutical Bulletin
26
3
DOI
出版ステータス出版済み - 3月 2003

!!!All Science Journal Classification (ASJC) codes

  • 薬理学
  • 薬科学

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