Inhibitory effects of 16-hydroxy-9-oxo-10E,12E,14E-octadecatrienoic acid (Corchorifatty acid B) isolated from Melissa officinalis Linné on melanogenesis

Hideaki Fujita, Maya Hongo, Mayu Mochizuki, Kouji Yokoyama, Yoshitaka Tanaka

研究成果: ジャーナルへの寄稿記事

5 引用 (Scopus)

抄録

16-hydroxy-9-oxo-10E,12E,14E-octadecatrienoic acid, also known as Corchorifatty acid B (CFAB), is isolated from the ethanol extracts of the aerial parts of Melissa officinalis Linné (Labiatae) and exhibits inhibitory effects on cellular pigmentation in both human melanocytes and mouse melanoma B16 cells. CFAB specifically decreases cellular melanin by most likely inducing rapid degradation of tyrosinase in B16 cells. Interestingly, unlike other reagents that promote degradation of tyrosinase in proteasomes or lysosomes, neither proteasomal nor lysosomal inhibitors can halt CFAB-induced tyrosinase degradation. Only brefeldin A, which specifically inhibits protein transport from the endoplasmic reticulum to the Golgi complex, can effectively impede CFAB-induced tyrosinase decrease. These results suggest that CFAB-induced tyrosinase decrease occurs in post-Golgi compartments but not in proteasomal or lysosomal compartments. Taken together, CFAB is a unique reagent that primarily accelerates tyrosinase decrease by a mechanism that differs from those considered for other hypopigmentation reagents currently reported.

元の言語英語
ページ(範囲)420-424
ページ数5
ジャーナルExperimental Dermatology
20
発行部数5
DOI
出版物ステータス出版済み - 5 1 2011

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Melissa
Monophenol Monooxygenase
Degradation
Hypopigmentation
Brefeldin A
Lamiaceae
Experimental Melanomas
Melanocytes
Melanins
Pigmentation
Golgi Apparatus
Corrosion inhibitors
Protein Transport
Proteasome Endopeptidase Complex
Lysosomes
16-hydroxy-9-oxo-10,12,14-octadecatrienoic acid
Endoplasmic Reticulum
Ethanol
Antennas

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Biology
  • Dermatology

これを引用

Inhibitory effects of 16-hydroxy-9-oxo-10E,12E,14E-octadecatrienoic acid (Corchorifatty acid B) isolated from Melissa officinalis Linné on melanogenesis. / Fujita, Hideaki; Hongo, Maya; Mochizuki, Mayu; Yokoyama, Kouji; Tanaka, Yoshitaka.

:: Experimental Dermatology, 巻 20, 番号 5, 01.05.2011, p. 420-424.

研究成果: ジャーナルへの寄稿記事

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abstract = "16-hydroxy-9-oxo-10E,12E,14E-octadecatrienoic acid, also known as Corchorifatty acid B (CFAB), is isolated from the ethanol extracts of the aerial parts of Melissa officinalis Linn{\'e} (Labiatae) and exhibits inhibitory effects on cellular pigmentation in both human melanocytes and mouse melanoma B16 cells. CFAB specifically decreases cellular melanin by most likely inducing rapid degradation of tyrosinase in B16 cells. Interestingly, unlike other reagents that promote degradation of tyrosinase in proteasomes or lysosomes, neither proteasomal nor lysosomal inhibitors can halt CFAB-induced tyrosinase degradation. Only brefeldin A, which specifically inhibits protein transport from the endoplasmic reticulum to the Golgi complex, can effectively impede CFAB-induced tyrosinase decrease. These results suggest that CFAB-induced tyrosinase decrease occurs in post-Golgi compartments but not in proteasomal or lysosomal compartments. Taken together, CFAB is a unique reagent that primarily accelerates tyrosinase decrease by a mechanism that differs from those considered for other hypopigmentation reagents currently reported.",
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