Injured adult motor and sensory axons regenerate into appropriate organotypic domains of neural progenitor grafts

Jennifer N. Dulin, Andrew F. Adler, Hiromi Kumamaru, Gunnar H.D. Poplawski, Corinne Lee-Kubli, Hans Strobl, Daniel Gibbs, Ken Kadoya, James W. Fawcett, Paul Lu, Mark H. Tuszynski

研究成果: ジャーナルへの寄稿記事

15 引用 (Scopus)

抄録

Neural progenitor cell (NPC) transplantation has high therapeutic potential in neurological disorders. Functional restoration may depend on the formation of reciprocal connections between host and graft. While it has been reported that axons extending out of neural grafts in the brain form contacts onto phenotypically appropriate host target regions, it is not known whether adult, injured host axons regenerating into NPC grafts also form appropriate connections. We report that spinal cord NPCs grafted into the injured adult rat spinal cord self-Assemble organotypic, dorsal horn-like domains. These clusters are extensively innervated by regenerating adult host sensory axons and are avoided by corticospinal axons. Moreover, host axon regeneration into grafts increases significantly after enrichment with appropriate neuronal targets. Together, these findings demonstrate that injured adult axons retain the ability to recognize appropriate targets and avoid inappropriate targets within neural progenitor grafts, suggesting that restoration of complex circuitry after SCI may be achievable.

元の言語英語
記事番号84
ジャーナルNature communications
9
発行部数1
DOI
出版物ステータス出版済み - 12 1 2018

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axons
Grafts
Axons
Transplants
spinal cord
restoration
Restoration
Spinal Cord
Stem Cells
Transplantation (surgical)
transplantation
Cell Transplantation
Nervous System Diseases
cells
regeneration
rats
brain
Rats
Regeneration
Brain

All Science Journal Classification (ASJC) codes

  • Chemistry(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Physics and Astronomy(all)

これを引用

Injured adult motor and sensory axons regenerate into appropriate organotypic domains of neural progenitor grafts. / Dulin, Jennifer N.; Adler, Andrew F.; Kumamaru, Hiromi; Poplawski, Gunnar H.D.; Lee-Kubli, Corinne; Strobl, Hans; Gibbs, Daniel; Kadoya, Ken; Fawcett, James W.; Lu, Paul; Tuszynski, Mark H.

:: Nature communications, 巻 9, 番号 1, 84, 01.12.2018.

研究成果: ジャーナルへの寄稿記事

Dulin, JN, Adler, AF, Kumamaru, H, Poplawski, GHD, Lee-Kubli, C, Strobl, H, Gibbs, D, Kadoya, K, Fawcett, JW, Lu, P & Tuszynski, MH 2018, 'Injured adult motor and sensory axons regenerate into appropriate organotypic domains of neural progenitor grafts', Nature communications, 巻. 9, 番号 1, 84. https://doi.org/10.1038/s41467-017-02613-x
Dulin, Jennifer N. ; Adler, Andrew F. ; Kumamaru, Hiromi ; Poplawski, Gunnar H.D. ; Lee-Kubli, Corinne ; Strobl, Hans ; Gibbs, Daniel ; Kadoya, Ken ; Fawcett, James W. ; Lu, Paul ; Tuszynski, Mark H. / Injured adult motor and sensory axons regenerate into appropriate organotypic domains of neural progenitor grafts. :: Nature communications. 2018 ; 巻 9, 番号 1.
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