ヒト化マウスを用いたヒト特異的疾患研究のイノベーション: 応用数学と実験医学の融合(<特集>疾患の数理モデル)

岩見 真吾, 佐藤 佳, 小柳 義夫

研究成果: Contribution to journalArticle査読

抄録

Recently, in order to investigate the fundamental phenomena in immunology and virology such as maintenance of immune memory, T-cell homeostasis, the relationship between aging and immunosenescence, the regulation of the adaptive immune response during viral infection, the pathogenesis of CD4^+ depletion in HIV infection, and the underlying mechanisms of leukemia, we successfully quantied lymphocyte kinetics in humanized mice through BrdUlabeling experiment. It is worth noting that our findings are the first to assess lymphocyte dynamics utilizing this technique. At first, we will briefly give an outline of the "Quantification system of lymphocyte kinetics in humanized mice" and then we will discuss about properties of the lymphocyte kinetics and utilities of our established system.
寄稿の翻訳タイトルInnovation of Human Specific Disease Research Using Humanized Mouse: Complemented Research between Applied Mathematics and Experimental Medicine(<Special Topics>Mathematical Model of Disease)
本文言語日本語
ページ(範囲)85-94
ページ数10
ジャーナル応用数理
22
2
DOI
出版ステータス出版済み - 2012

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「ヒト化マウスを用いたヒト特異的疾患研究のイノベーション: 応用数学と実験医学の融合(<特集>疾患の数理モデル)」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

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