Insertion of a long KpnI family member within a mitochondrial-DNA-like sequence present in the human nuclear genome

Wakasugi Shoji, Nomiyama Hisayuki, Fukuda Makoto, Tsuzuki Teruhisa, Shimada Kazunori

研究成果: Contribution to journalArticle査読

11 被引用数 (Scopus)

抄録

Structural analysis of a phage λ, Charon 4A clone carrying one of the human nuclear mitochondrial(mt)-DNA-like sequences revealed that a KpnI-family member (KpnI 5.5-kb DNA) is inserted within this sequence. The inserted KpnI 5.5-kb DNA contains several possible polyadenylation signal sequences followed by an A-rich sequence at its 3' end and is flanked by perfect 13-bp direct repeats of the duplicated mtDNA-like sequences. These structures strongly suggest that the KpnI 5.5-kb DNA is a mobile element. Comparison of the 5' terminal sequences of the KpnI 5.5-kb DNA and four other long KpnI-family DNAs so far examined, using the predicted general promoter sequence for eukaryotic tRNAs, indicates that they contain the consensus sequences for the split internal RNA polymerase III control region.

本文言語英語
ページ(範囲)281-288
ページ数8
ジャーナルGene
36
3
DOI
出版ステータス出版済み - 1985

All Science Journal Classification (ASJC) codes

  • 遺伝学

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