Insertion of a long KpnI family member within a mitochondrial-DNA-like sequence present in the human nuclear genome

Wakasugi Shoji, Nomiyama Hisayuki, Fukuda Makoto, Teruhisa Tsuzuki, Shimada Kazunori

研究成果: ジャーナルへの寄稿記事

11 引用 (Scopus)

抄録

Structural analysis of a phage λ, Charon 4A clone carrying one of the human nuclear mitochondrial(mt)-DNA-like sequences revealed that a KpnI-family member (KpnI 5.5-kb DNA) is inserted within this sequence. The inserted KpnI 5.5-kb DNA contains several possible polyadenylation signal sequences followed by an A-rich sequence at its 3' end and is flanked by perfect 13-bp direct repeats of the duplicated mtDNA-like sequences. These structures strongly suggest that the KpnI 5.5-kb DNA is a mobile element. Comparison of the 5' terminal sequences of the KpnI 5.5-kb DNA and four other long KpnI-family DNAs so far examined, using the predicted general promoter sequence for eukaryotic tRNAs, indicates that they contain the consensus sequences for the split internal RNA polymerase III control region.

元の言語英語
ページ(範囲)281-288
ページ数8
ジャーナルGene
36
発行部数3
DOI
出版物ステータス出版済み - 1 1 1985

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Human Genome
Mitochondrial DNA
DNA
Pluto
RNA Polymerase III
Polyadenylation
Nucleic Acid Repetitive Sequences
Consensus Sequence
Protein Sorting Signals
Transfer RNA
Bacteriophages
Clone Cells

All Science Journal Classification (ASJC) codes

  • Genetics

これを引用

Insertion of a long KpnI family member within a mitochondrial-DNA-like sequence present in the human nuclear genome. / Shoji, Wakasugi; Hisayuki, Nomiyama; Makoto, Fukuda; Tsuzuki, Teruhisa; Kazunori, Shimada.

:: Gene, 巻 36, 番号 3, 01.01.1985, p. 281-288.

研究成果: ジャーナルへの寄稿記事

Shoji, Wakasugi ; Hisayuki, Nomiyama ; Makoto, Fukuda ; Tsuzuki, Teruhisa ; Kazunori, Shimada. / Insertion of a long KpnI family member within a mitochondrial-DNA-like sequence present in the human nuclear genome. :: Gene. 1985 ; 巻 36, 番号 3. pp. 281-288.
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abstract = "Structural analysis of a phage λ, Charon 4A clone carrying one of the human nuclear mitochondrial(mt)-DNA-like sequences revealed that a KpnI-family member (KpnI 5.5-kb DNA) is inserted within this sequence. The inserted KpnI 5.5-kb DNA contains several possible polyadenylation signal sequences followed by an A-rich sequence at its 3' end and is flanked by perfect 13-bp direct repeats of the duplicated mtDNA-like sequences. These structures strongly suggest that the KpnI 5.5-kb DNA is a mobile element. Comparison of the 5' terminal sequences of the KpnI 5.5-kb DNA and four other long KpnI-family DNAs so far examined, using the predicted general promoter sequence for eukaryotic tRNAs, indicates that they contain the consensus sequences for the split internal RNA polymerase III control region.",
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AU - Kazunori, Shimada

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