Insight into acid-mediated asymmetric spirocyclization in the presence of a chiral diol

T. Kiguchi, Y. Tsurusaki, S. Yamada, Mariko Aso, M. Tanaka, K. Sakai, H. Suemune

研究成果: ジャーナルへの寄稿記事

5 引用 (Scopus)

抄録

Asymmetric spirocyclization based on intramolecular conjugate addition using a combination of a Lewis acid and an optically active cyclohexane-1,2-diol has been studied in connection with 1) the effect of substituents on the cyclohexane-1,2-diol and 2) the effect of substituents on the substrate. This reaction was found to be both thermodynamically and kinetically controlled under restricted conditions.

元の言語英語
ページ(範囲)1536-1540
ページ数5
ジャーナルChemical and Pharmaceutical Bulletin
48
発行部数10
DOI
出版物ステータス出版済み - 1 1 2000

Fingerprint

Lewis Acids
Acids
Substrates
Cyclohexane

All Science Journal Classification (ASJC) codes

  • Chemistry(all)
  • Drug Discovery

これを引用

Insight into acid-mediated asymmetric spirocyclization in the presence of a chiral diol. / Kiguchi, T.; Tsurusaki, Y.; Yamada, S.; Aso, Mariko; Tanaka, M.; Sakai, K.; Suemune, H.

:: Chemical and Pharmaceutical Bulletin, 巻 48, 番号 10, 01.01.2000, p. 1536-1540.

研究成果: ジャーナルへの寄稿記事

Kiguchi, T, Tsurusaki, Y, Yamada, S, Aso, M, Tanaka, M, Sakai, K & Suemune, H 2000, 'Insight into acid-mediated asymmetric spirocyclization in the presence of a chiral diol', Chemical and Pharmaceutical Bulletin, 巻. 48, 番号 10, pp. 1536-1540. https://doi.org/10.1248/cpb.48.1536
Kiguchi, T. ; Tsurusaki, Y. ; Yamada, S. ; Aso, Mariko ; Tanaka, M. ; Sakai, K. ; Suemune, H. / Insight into acid-mediated asymmetric spirocyclization in the presence of a chiral diol. :: Chemical and Pharmaceutical Bulletin. 2000 ; 巻 48, 番号 10. pp. 1536-1540.
@article{d82e3a6e8b8441c7acaf187d23fd535d,
title = "Insight into acid-mediated asymmetric spirocyclization in the presence of a chiral diol",
abstract = "Asymmetric spirocyclization based on intramolecular conjugate addition using a combination of a Lewis acid and an optically active cyclohexane-1,2-diol has been studied in connection with 1) the effect of substituents on the cyclohexane-1,2-diol and 2) the effect of substituents on the substrate. This reaction was found to be both thermodynamically and kinetically controlled under restricted conditions.",
author = "T. Kiguchi and Y. Tsurusaki and S. Yamada and Mariko Aso and M. Tanaka and K. Sakai and H. Suemune",
year = "2000",
month = "1",
day = "1",
doi = "10.1248/cpb.48.1536",
language = "English",
volume = "48",
pages = "1536--1540",
journal = "Chemical and Pharmaceutical Bulletin",
issn = "0009-2363",
publisher = "The Pharmaceutical Society of Japan",
number = "10",

}

TY - JOUR

T1 - Insight into acid-mediated asymmetric spirocyclization in the presence of a chiral diol

AU - Kiguchi, T.

AU - Tsurusaki, Y.

AU - Yamada, S.

AU - Aso, Mariko

AU - Tanaka, M.

AU - Sakai, K.

AU - Suemune, H.

PY - 2000/1/1

Y1 - 2000/1/1

N2 - Asymmetric spirocyclization based on intramolecular conjugate addition using a combination of a Lewis acid and an optically active cyclohexane-1,2-diol has been studied in connection with 1) the effect of substituents on the cyclohexane-1,2-diol and 2) the effect of substituents on the substrate. This reaction was found to be both thermodynamically and kinetically controlled under restricted conditions.

AB - Asymmetric spirocyclization based on intramolecular conjugate addition using a combination of a Lewis acid and an optically active cyclohexane-1,2-diol has been studied in connection with 1) the effect of substituents on the cyclohexane-1,2-diol and 2) the effect of substituents on the substrate. This reaction was found to be both thermodynamically and kinetically controlled under restricted conditions.

UR - http://www.scopus.com/inward/record.url?scp=0033788242&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0033788242&partnerID=8YFLogxK

U2 - 10.1248/cpb.48.1536

DO - 10.1248/cpb.48.1536

M3 - Article

VL - 48

SP - 1536

EP - 1540

JO - Chemical and Pharmaceutical Bulletin

JF - Chemical and Pharmaceutical Bulletin

SN - 0009-2363

IS - 10

ER -