Insulin-like growth factor II messenger RNA-binding protein-3 is an independent prognostic factor in uterine leiomyosarcoma

Nobuko Yasutake, Yoshihiro Ohishi, Kenichi Taguchi, Yuka Hiraki, Masafumi Oya, Yumi Oshiro, Mari Mine, Takeshi Iwasaki, Hidetaka Yamamoto, Kenichi Kohashi, Kenzo Sonoda, Kiyoko Kato, Yoshinao Oda

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Aims: The aim of this study was to identify the prognostic factors of uterine leiomyosarcoma (ULMS). Methods and results: We reviewed 60 cases of surgically resected ULMSs and investigated conventional clinicopathological factors, together with the expression of insulin-like growth factor II messenger RNA-binding protein-3 (IMP3), hormone receptors and cell cycle regulatory markers by immunohistochemistry. Mediator complex subunit 12 (MED12) mutation analysis was also performed. Univariate analyses revealed that advanced stage (P < 0.0001), older age (P = 0.0244) and IMP3 expression (P = 0.0011) were significant predictors of a poor outcome. Multivariate analysis revealed advanced stage (P < 0.0001) and IMP3 (P = 0.0373) as independent predictors of a poor prognosis. Expressions of cell cycle markers and hormone receptors, and MED12 mutations (12% in ULMSs) were not identified as prognostic markers in this study. Conclusions: IMP3 expression in ULMS could be a marker of a poor prognosis.

元の言語英語
ページ(範囲)739-748
ページ数10
ジャーナルHistopathology
72
発行部数5
DOI
出版物ステータス出版済み - 4 2018

All Science Journal Classification (ASJC) codes

  • Pathology and Forensic Medicine
  • Histology

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