Interaction between chlorpromazine and human serum albumin

Masami Tanaka, Seizo Masuda, Keiji Minagawa, Takeshi Mori

研究成果: Chapter in Book/Report/Conference proceedingConference contribution

抄録

The interaction between Chlorpromazine (CPM) and human serum albumin (HSA) was investigated by equilibrium dialysis. Since the binding constant of CPM to HSA was independent of ionic strength and decreased with increase of alkyl chain length of fatty acid added, the interaction between CPM and HSA was considered to be due to hydrophobic mechanism. Chemical shifts in 1H-NMR spectra of CPM were independent of the concentration of CPM and addition of HSA. Spin-lattice relaxation time (T1) and spin-spin relaxation time (T2) of respective protons of CPM were independent of the concentration, but depended on the concentration of HSA added. The binding position of CPM to HSA was considered to involve the hydrophobic aromatic moiety of CPM from the ratio of spin-spin relaxation rates (1/T2) of CPM bound to HSA and free CPM.

本文言語英語
ホスト出版物のタイトルPolymer Preprints, Japan - 55th SPSJ Annual Meeting
ページ2125
ページ数1
55
1
出版ステータス出版済み - 2006
外部発表はい
イベント55th SPSJ Annual Meeting - Nagoya, 日本
継続期間: 5 24 20065 26 2006

その他

その他55th SPSJ Annual Meeting
Country日本
CityNagoya
Period5/24/065/26/06

All Science Journal Classification (ASJC) codes

  • Engineering(all)

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