Interaction between multimeric sulfated saccharides and Alzheimer amyloid β (1-42)

Tomohiro Fukuda, Erino Matsumoto, Yoshiko Miura

研究成果: Contribution to journalArticle査読

4 被引用数 (Scopus)

抄録

The pathogenesis of Alzheimer's disease is known to be related to the glycosaminoglycans that are associated with the deposition of amyloid beta (Aβ) peptides. We prepared heparin-mimicking multimeric saccharides and investigated their interactions with Aβ peptides in solution. The results showed that multimeric saccharides, especially the dimeric saccharide, strongly inhibited β-sheeted Aβ aggregation as assessed by the thioflavin-T (Th-T) assay, average zeta potential measurements and atomic force microscopy (AFM). This result suggested that the amyloidosis of Aβ (1-42) was affected by the multivalency of saccharides even in the solution.

本文言語英語
ページ(範囲)1482-1484
ページ数3
ジャーナルChemistry Letters
44
11
DOI
出版ステータス出版済み - 2015

All Science Journal Classification (ASJC) codes

  • Chemistry(all)

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