Interleukin-10 from transplanted bone marrow mononuclear cells contributes to cardiac protection after myocardial infarction

Jana S. Burchfield, Masayoshi Iwasaki, Masamichi Koyanagi, Carmen Urbich, Nadia Rosenthal, Andreas M. Zeiher, Stefanie Dimmeler

研究成果: Contribution to journalArticle査読

127 被引用数 (Scopus)

抄録

Bone marrow mononuclear cells (BM-MNCs) have successfully been used as a therapy for the improvement of left ventricular (LV) function after myocardial infarction (MI). It has been suggested that paracrine factors from BM-MNCs may be a key mechanism mediating cardiac protection. We previously performed microarray analysis and found that the pleiotropic cytokine interleukin (IL)-10 was highly upregulated in human progenitor cells in comparison with adult endothelial cells and CD14 cells. Moreover, BM-MNCs secrete significant amounts of IL-10, and IL-10 could be detected from progenitor cells transplanted in infarcted mouse hearts. Specifically, intramyocardial injection of wild-type BM-MNCs led to a significant decrease in LV end-diastolic pressure (LVEDP) and LV end-systolic volume (LVESV) compared to hearts injected with either diluent or IL-10 knock-out BM-MNCs. Furthermore, intramyocardial injection of wild-type BM-MNCs led to a significant increase in stroke volume (SV) and rate of the development of pressure over time (+dP/dt) compared to hearts injected with either diluent or IL-10 knock-out BM-MNCs. The IL-10-dependent improvement provided by transplanted cells was not caused by reduced infarct size, neutrophil infiltration, or capillary density, but rather was associated with decreased T lymphocyte accumulation, reactive hypertrophy, and myocardial collagen deposition. These results suggest that BM-MNCs mediate cardiac protection after myocardial infarction and this is, at least in part, dependent on IL-10.

本文言語英語
ページ(範囲)203-211
ページ数9
ジャーナルCirculation research
103
2
DOI
出版ステータス出版済み - 7 18 2008

All Science Journal Classification (ASJC) codes

  • 生理学
  • 循環器および心血管医学

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