Interleukin-4 in chronic myelomonocytic leukemia: Growth suppression of hematopoietic precursors in the chronic phase and stimulation in the acute phase

K. Yanagisawa, K. Kishimoto, T. Horiuchi, K. Takada, M. Yasukawa, S. Fujita

研究成果: ジャーナルへの寄稿学術誌査読

2 被引用数 (Scopus)

抄録

We examined the effects of interleukin-4 (IL-4) on the growth of hematopoietic precursors from a patient with chronic myelomonocytic leukemia (CMMoL). In the chronic phase of the disease, IL-4 inhibited spontaneous colony formation by CMMoL cells in semi-solid culture. However, in the acute phase, IL-4 promoted colony formation. These effects of IL-4 were abolished completely by the addition of anti-IL-4 neutralizing antibodies. The spontaneous colony formation by CMMoL cells in both the chronic and acute phases was inhibited by the addition of anti-IL-6 antibodies. On the other hand, neither anti-IL-6, anti-granulocyte macrophage colony-stimulating factor (GMCSF), anti-IL-1β nor anti-tumor necrosis factor α (TNFα) antibodies inhibited IL-4-induced colony formation by CMMoL cells in the acute phase. IL-4 suppressed the production of IL-6 by CMMoL cells in both the chronic and acute phases. These results suggest that in the present patient, IL-4 suppressed the IL-6-mediated autocrine growth of CMMoL cells in both the chronic and acute phases, but directly stimulated their growth in the acute phase.

本文言語英語
ページ(範囲)104-108
ページ数5
ジャーナルActa Haematologica
92
2
DOI
出版ステータス出版済み - 1月 1 1994
外部発表はい

!!!All Science Journal Classification (ASJC) codes

  • 血液学

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