Intimal response of saphenous vein to intraluminal trauma by simulated angioscopic insertion

Makoto Hashizume, Yeng Yang, Spencer Galt, S. N.S. Murthy, Teruo Matsumoto

研究成果: Contribution to journalArticle査読

24 被引用数 (Scopus)

抄録

Endothelial damage after simulated angioscopic insertion was evaluated in 22 dogs by radioimmunoassay of endogenous 6-keto-prostaglandin F (stable product of prostacyclin produced by the endothelium) by means of a closed perfusion system and scanning electron microscopy. In 20 dogs, a 1.7 mm diameter polyethylene tube similar in size and physical characteristics to a commercially available angioscope was passed once into the distal venotomy site and out of the proximal venotomy site for a total distance of 15 cm in the left saphenous vein (group A) and 10 times in both directions in the right saphenous vein, destroying all valves (group B). The vein segments were examined immediately after simulated angioscopic insertion and at intervals of 2, 3, and 4 weeks. The remaining two dogs were used as control animals to establish baseline prostacyclin production. All veins were patent when harvested. Scanning electron microscopy revealed globular and contracted endothelial cells in some areas of group A veins, whereas partial longitudinal absence of endothelial cells was noted in group B veins. Intimal coverage was complete by 2 weeks in group A veins and between 3 and 4 weeks in group B veins. Prostacyclin synthesis of group B veins was significantly less than that of group A at day 1 and at 2 weeks after operation (p < 0.05), reaching that of control vein synthesis by 4 weeks. This study suggests that simulated angioscopic trauma of the luminal surface of the canine saphenous vein had no negative effect on early patency.

本文言語英語
ページ(範囲)862-868
ページ数7
ジャーナルJournal of Vascular Surgery
5
6
DOI
出版ステータス出版済み - 6 1987

All Science Journal Classification (ASJC) codes

  • 外科
  • 循環器および心血管医学

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