Intracellular inducible alkylation system that exhibits antisense effects with greater potency and selectivity than the natural oligonucleotide

Md Monsur Ali, Motoi Oishi, Fumi Nagatsugi, Kenya Mori, Yukio Nagasaki, Kazunori Kataoka, Shigeki Sasaki

研究成果: Contribution to journalArticle査読

50 被引用数 (Scopus)

抄録

(Chemical Equation Presented) One mismatch is discriminated in a target mRNA sequence by an inducible alkylation system based on sulfide precursors to the nucleoside 2-amino-6-vinylpurine (see scheme). The reactive oligonucleotides were delivered into the cell as poly(ethylene glycol) (PEG) conjugates in polyion-complex (PIC) micelles and showed antisense activity of high selectivity and greater potency than that of the natural antisense oligonucleotide.

本文言語英語
ページ(範囲)3136-3140
ページ数5
ジャーナルAngewandte Chemie - International Edition
45
19
DOI
出版ステータス出版済み - 5 5 2006

All Science Journal Classification (ASJC) codes

  • 触媒
  • 化学 (全般)

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