Intracellular logistics of BST-2/Tetherin

Hideaki Fujita, Keiko Fujimoto, Kenzo Tokunaga, Yoshitaka Tanaka

研究成果: ジャーナルへの寄稿評論記事

3 引用 (Scopus)

抄録

Bone marrow stromal antigen 2 (BST-2) is a type II membrane protein with two targeting signals, one of which is located in the cytoplasmic domain and contains a non-canonical dual tyrosine-based motif responsible for its endocytosis from the plasma membrane, and the other is a C-terminal glycosylphosphatidylinositol anchor that facilitates its association with detergent-resistant membranes/lipid rafts and targeting to the apical domain in polarized epithelial cells. Due to its unusual topology at the membrane, BST-2 takes unique and complicated trafficking routes in cells. Recently, a physiological role for BST-2 as the "tetherin" molecule for viruses, especially for HIV-1, has been extensively examined. These studies have shown that the biosynthesis, intracellular trafficking, localization, and structure of human BST-2 are closely related to its antiviral activity. This review provides an overview of the intracellular logistics of human BST-2.

元の言語英語
ページ(範囲)321-326
ページ数6
ジャーナルCurrent HIV Research
10
発行部数4
DOI
出版物ステータス出版済み - 6 2012

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Bone Marrow
Antigens
Glycosylphosphatidylinositols
Membrane Lipids
Endocytosis
Detergents
Antiviral Agents
Tyrosine
HIV-1
Membrane Proteins
Epithelial Cells
Cell Membrane
Viruses
Membranes
human BST2 protein

All Science Journal Classification (ASJC) codes

  • Infectious Diseases
  • Virology

これを引用

Intracellular logistics of BST-2/Tetherin. / Fujita, Hideaki; Fujimoto, Keiko; Tokunaga, Kenzo; Tanaka, Yoshitaka.

:: Current HIV Research, 巻 10, 番号 4, 06.2012, p. 321-326.

研究成果: ジャーナルへの寄稿評論記事

Fujita, Hideaki ; Fujimoto, Keiko ; Tokunaga, Kenzo ; Tanaka, Yoshitaka. / Intracellular logistics of BST-2/Tetherin. :: Current HIV Research. 2012 ; 巻 10, 番号 4. pp. 321-326.
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