Intracellular transport and processing of lysosomal cathepsin B

Yukio Nishimura, Keitaro Kato

研究成果: Contribution to journalArticle査読

27 被引用数 (Scopus)

抄録

Intracellular transport and processing of lysosomal cathepsin B was investigated in the subcellular fractions of rat liver by pulse-labeling experiments with [35S]methionine in vivo. A newly synthesized procathepsin B with a molecular weight of 39 kDa firstly appeared in the rough microsomal fraction at 10 min postinjection of label. This procathepsin B moved from the microsomal fractions to the Golgi subfractions at 30 min postinjection, and then a processed mature enzyme appeared in the lysosomal fraction at 60 min. These results suggest that the propeptide-processing of procathepsin B takes place in lysosomes in the course of intracellular transport from endoplasmic reticulum through Golgi complex to lysosomes.

本文言語英語
ページ(範囲)254-259
ページ数6
ジャーナルBiochemical and Biophysical Research Communications
148
1
DOI
出版ステータス出版済み - 10 14 1987

All Science Journal Classification (ASJC) codes

  • 生物理学
  • 生化学
  • 分子生物学
  • 細胞生物学

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