Intracerebral hemorrhage location and outcome among INTERACT2 participants

Candice Delcourt, Shoichiro Sato, Shihong Zhang, Else Charlotte Sandset, Danni Zheng, Xiaoying Chen, Maree L. Hackett, Hisatomi Arima, Jun Hata, Emma Heeley, Rustam Al Shahi Salman, Thompson Robinson, Leo Davies, Pablo M. Lavados, Richard I. Lindley, Christian Stapf, John Chalmers, Craig S. Anderson

研究成果: ジャーナルへの寄稿記事

24 引用 (Scopus)

抄録

Objective: To clarify associations between intracerebral hemorrhage (ICH) location and clinical outcomes among participants of the main phase Intensive Blood Pressure Reduction in Acute Cerebral Hemorrhage Trial (INTERACT2). Methods: Associations between ICH sites and poor outcomes (death [6] or major disability [3-5] of modified Rankin Scale) and European Quality of Life Scale (EQ-5D) utility scores at 90 days were assessed in logistic regression models. Results: Of 2,066 patients included in the analyses, associations were identified between ICH sites and poor outcomes: Involvement of posterior limb of internal capsule increased risks of death or major disability (odds ratio [OR] 2.10) and disability (OR 1.81); thalamic involvement increased risks of death or major disability (OR 2.24) and death (OR 1.97). Involvement of the posterior limb of the internal capsule, thalamus, and infratentorial sites were each associated with poor EQ-5D utility score (≤0.7 [median]; OR 1.87, 2.14, and 2.81, respectively). Posterior limb of internal capsule involvement was strongly associated with low scores across all health-related quality of life domains. ICH encompassing the thalamus and posterior limb of internal capsule were associated with death or major disability, major disability, and poor EQ-5D utility score (OR 1.72, 2.26, and 1.71, respectively). Conclusion: Poor clinical outcomes are related to ICH affecting the posterior limb of internal capsule, thalamus, and infratentorial sites. The highest association with death or major disability and poor EQ-5D utility score was seen in ICH encompassing the thalamus and posterior limb of internal capsule. ClinicalTrials.gov registration: NCT00716079.

元の言語英語
ページ(範囲)1408-1414
ページ数7
ジャーナルNeurology
88
発行部数15
DOI
出版物ステータス出版済み - 4 11 2017

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Internal Capsule
Cerebral Hemorrhage
Extremities
Odds Ratio
Thalamus
Logistic Models
Quality of Life
Blood Pressure

All Science Journal Classification (ASJC) codes

  • Clinical Neurology

これを引用

Delcourt, C., Sato, S., Zhang, S., Sandset, E. C., Zheng, D., Chen, X., ... Anderson, C. S. (2017). Intracerebral hemorrhage location and outcome among INTERACT2 participants. Neurology, 88(15), 1408-1414. https://doi.org/10.1212/WNL.0000000000003771

Intracerebral hemorrhage location and outcome among INTERACT2 participants. / Delcourt, Candice; Sato, Shoichiro; Zhang, Shihong; Sandset, Else Charlotte; Zheng, Danni; Chen, Xiaoying; Hackett, Maree L.; Arima, Hisatomi; Hata, Jun; Heeley, Emma; Salman, Rustam Al Shahi; Robinson, Thompson; Davies, Leo; Lavados, Pablo M.; Lindley, Richard I.; Stapf, Christian; Chalmers, John; Anderson, Craig S.

:: Neurology, 巻 88, 番号 15, 11.04.2017, p. 1408-1414.

研究成果: ジャーナルへの寄稿記事

Delcourt, C, Sato, S, Zhang, S, Sandset, EC, Zheng, D, Chen, X, Hackett, ML, Arima, H, Hata, J, Heeley, E, Salman, RAS, Robinson, T, Davies, L, Lavados, PM, Lindley, RI, Stapf, C, Chalmers, J & Anderson, CS 2017, 'Intracerebral hemorrhage location and outcome among INTERACT2 participants', Neurology, 巻. 88, 番号 15, pp. 1408-1414. https://doi.org/10.1212/WNL.0000000000003771
Delcourt C, Sato S, Zhang S, Sandset EC, Zheng D, Chen X その他. Intracerebral hemorrhage location and outcome among INTERACT2 participants. Neurology. 2017 4 11;88(15):1408-1414. https://doi.org/10.1212/WNL.0000000000003771
Delcourt, Candice ; Sato, Shoichiro ; Zhang, Shihong ; Sandset, Else Charlotte ; Zheng, Danni ; Chen, Xiaoying ; Hackett, Maree L. ; Arima, Hisatomi ; Hata, Jun ; Heeley, Emma ; Salman, Rustam Al Shahi ; Robinson, Thompson ; Davies, Leo ; Lavados, Pablo M. ; Lindley, Richard I. ; Stapf, Christian ; Chalmers, John ; Anderson, Craig S. / Intracerebral hemorrhage location and outcome among INTERACT2 participants. :: Neurology. 2017 ; 巻 88, 番号 15. pp. 1408-1414.
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abstract = "Objective: To clarify associations between intracerebral hemorrhage (ICH) location and clinical outcomes among participants of the main phase Intensive Blood Pressure Reduction in Acute Cerebral Hemorrhage Trial (INTERACT2). Methods: Associations between ICH sites and poor outcomes (death [6] or major disability [3-5] of modified Rankin Scale) and European Quality of Life Scale (EQ-5D) utility scores at 90 days were assessed in logistic regression models. Results: Of 2,066 patients included in the analyses, associations were identified between ICH sites and poor outcomes: Involvement of posterior limb of internal capsule increased risks of death or major disability (odds ratio [OR] 2.10) and disability (OR 1.81); thalamic involvement increased risks of death or major disability (OR 2.24) and death (OR 1.97). Involvement of the posterior limb of the internal capsule, thalamus, and infratentorial sites were each associated with poor EQ-5D utility score (≤0.7 [median]; OR 1.87, 2.14, and 2.81, respectively). Posterior limb of internal capsule involvement was strongly associated with low scores across all health-related quality of life domains. ICH encompassing the thalamus and posterior limb of internal capsule were associated with death or major disability, major disability, and poor EQ-5D utility score (OR 1.72, 2.26, and 1.71, respectively). Conclusion: Poor clinical outcomes are related to ICH affecting the posterior limb of internal capsule, thalamus, and infratentorial sites. The highest association with death or major disability and poor EQ-5D utility score was seen in ICH encompassing the thalamus and posterior limb of internal capsule. ClinicalTrials.gov registration: NCT00716079.",
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T1 - Intracerebral hemorrhage location and outcome among INTERACT2 participants

AU - Delcourt, Candice

AU - Sato, Shoichiro

AU - Zhang, Shihong

AU - Sandset, Else Charlotte

AU - Zheng, Danni

AU - Chen, Xiaoying

AU - Hackett, Maree L.

AU - Arima, Hisatomi

AU - Hata, Jun

AU - Heeley, Emma

AU - Salman, Rustam Al Shahi

AU - Robinson, Thompson

AU - Davies, Leo

AU - Lavados, Pablo M.

AU - Lindley, Richard I.

AU - Stapf, Christian

AU - Chalmers, John

AU - Anderson, Craig S.

PY - 2017/4/11

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N2 - Objective: To clarify associations between intracerebral hemorrhage (ICH) location and clinical outcomes among participants of the main phase Intensive Blood Pressure Reduction in Acute Cerebral Hemorrhage Trial (INTERACT2). Methods: Associations between ICH sites and poor outcomes (death [6] or major disability [3-5] of modified Rankin Scale) and European Quality of Life Scale (EQ-5D) utility scores at 90 days were assessed in logistic regression models. Results: Of 2,066 patients included in the analyses, associations were identified between ICH sites and poor outcomes: Involvement of posterior limb of internal capsule increased risks of death or major disability (odds ratio [OR] 2.10) and disability (OR 1.81); thalamic involvement increased risks of death or major disability (OR 2.24) and death (OR 1.97). Involvement of the posterior limb of the internal capsule, thalamus, and infratentorial sites were each associated with poor EQ-5D utility score (≤0.7 [median]; OR 1.87, 2.14, and 2.81, respectively). Posterior limb of internal capsule involvement was strongly associated with low scores across all health-related quality of life domains. ICH encompassing the thalamus and posterior limb of internal capsule were associated with death or major disability, major disability, and poor EQ-5D utility score (OR 1.72, 2.26, and 1.71, respectively). Conclusion: Poor clinical outcomes are related to ICH affecting the posterior limb of internal capsule, thalamus, and infratentorial sites. The highest association with death or major disability and poor EQ-5D utility score was seen in ICH encompassing the thalamus and posterior limb of internal capsule. ClinicalTrials.gov registration: NCT00716079.

AB - Objective: To clarify associations between intracerebral hemorrhage (ICH) location and clinical outcomes among participants of the main phase Intensive Blood Pressure Reduction in Acute Cerebral Hemorrhage Trial (INTERACT2). Methods: Associations between ICH sites and poor outcomes (death [6] or major disability [3-5] of modified Rankin Scale) and European Quality of Life Scale (EQ-5D) utility scores at 90 days were assessed in logistic regression models. Results: Of 2,066 patients included in the analyses, associations were identified between ICH sites and poor outcomes: Involvement of posterior limb of internal capsule increased risks of death or major disability (odds ratio [OR] 2.10) and disability (OR 1.81); thalamic involvement increased risks of death or major disability (OR 2.24) and death (OR 1.97). Involvement of the posterior limb of the internal capsule, thalamus, and infratentorial sites were each associated with poor EQ-5D utility score (≤0.7 [median]; OR 1.87, 2.14, and 2.81, respectively). Posterior limb of internal capsule involvement was strongly associated with low scores across all health-related quality of life domains. ICH encompassing the thalamus and posterior limb of internal capsule were associated with death or major disability, major disability, and poor EQ-5D utility score (OR 1.72, 2.26, and 1.71, respectively). Conclusion: Poor clinical outcomes are related to ICH affecting the posterior limb of internal capsule, thalamus, and infratentorial sites. The highest association with death or major disability and poor EQ-5D utility score was seen in ICH encompassing the thalamus and posterior limb of internal capsule. ClinicalTrials.gov registration: NCT00716079.

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