Intracerebroventricular administration of GABA-A and GABA-B receptor antagonists attenuate feeding and sleeping-like behavior induced by L-pipecolic acid in neonatal chicks

T. Takagi, T. Bungo, T. Tachibana, E. S. Saito, S. Saito, I. Yamasaki, S. Tomonaga, D. M. Denbow, Mitsuhiro Furuse

研究成果: ジャーナルへの寄稿学術誌査読

35 被引用数 (Scopus)

抄録

It has been demonstrated that L-pipecolic acid (L-PA), a major metabolic intermediate of L-lysine (L-Lys) in the mammalian and chicken brain, is involved in the functioning of the GABAergic system. A previous study has shown that intracerebroventricular (i.c.v.) injection of L-PA suppressed feeding and induced sleep-like behavior in neonatal chicks; however, the precise relationship between the GABAergic system and L-PA has not been clarified. In the present study, the role of the GABA-A or GABA-B receptors in the suppression of food intake and induction of sleeping-like behavior by L-PA was investigated. Chicks were injected i.c.v. with the GABA-A antagonist picrotoxin or GABA-B antagonist CGP54626 along with L-PA. Although suppression of food intake by L-PA was restored partially by co-injection with CGP54626, but not picrotoxin, sleep-like behavior induced by L-PA was suppressed significantly by both antagonists. These results suggested that L-PA activated both GABA-A and GABA-B receptors, and GABA-B receptors alone contributed to food intake whereas both receptors contributed to sleep-like behavior.

本文言語英語
ページ(範囲)270-275
ページ数6
ジャーナルJournal of Neuroscience Research
73
2
DOI
出版ステータス出版済み - 7月 15 2003

!!!All Science Journal Classification (ASJC) codes

  • 細胞および分子神経科学

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