Intracerebroventricular injection of fusaric acid attenuates the anorexia by glucagon-like peptide-1 in the neonatal chick

T. Bungo, S. I. Kawakami, A. Ohgushi, K. Sashihara, N. Saito, K. Sugahara, S. Hasegawa, D. M. Denbow, M. Furuse

研究成果: Contribution to journalArticle査読

23 被引用数 (Scopus)

抄録

It is known that central injection of glucagon-like peptide-1 (GLP-1) suppresses feeding in rats and chicks, but the systems for GLP-1 are still open with special reference to the chick. The present study was done to determine whether a noradrenergic mechanism contributes to the anorexigenic effect of GLP-1 on the neonatal chick. Central administration of norepinephrine (NE) suppressed food intake with narcolepsy as GLP-1 in chicks. However, in spite of that dopamine (DA) did not affect food intake, coadministration of inhibitor of dopamine-β-hydroxylase (DBH), fusaric acid (FA), attenuated the suppressive effect of GLP-1 on feeding behavior. It is suggested that there may be the interactive relationships between GLP-1 and noradrenergic system in the neonatal chick.

本文言語英語
ページ(範囲)251-255
ページ数5
ジャーナルPharmacology Biochemistry and Behavior
70
2-3
DOI
出版ステータス出版済み - 2001

All Science Journal Classification (ASJC) codes

  • 生化学
  • 毒物学
  • 薬理学
  • 臨床生化学
  • 生物学的精神医学
  • 行動神経科学

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