Intracerebroventricular Injection of L-Alanine Induces a Sedative Effect under an Acute Stressful Condition in Neonatal Chicks

Isao Kurauchi, Mitsuhiro Furuse, Tetsuya Tachibana, Li Han, Kohsuke Hayamizu, D. Michael Denbow

研究成果: Contribution to journalArticle査読

19 被引用数 (Scopus)

抄録

Pyruvate can be synthesized from amino acids such as L-alanine, L-serine and L-cysteine. Recently, we reported that intracerebroventricular (i.c.v.) injection of L-serine and L-cysteine attenuated acute stress in chicks. This fact implies that amino acid substrates for pyruvate play a sedative role in the brain. However, no information was available for L-alanine. To elucidate the central effect of L-alanine on stress responses, L-alanine (0.8μmol) or saline was administered i.c.v. just before exposure to social separation stress. The social separation stress increased spontaneous activity and vocalization of chicks, but these responses were attenuated by the i.c.v. injection of L-alanine. In conclusion, in addition to L-serine and L-cysteine, centrally administered L-alanine may be effective in attenuating anxiety induced by a psychological stressor.

本文言語英語
ページ(範囲)384-387
ページ数4
ジャーナルJournal of Poultry Science
43
4
DOI
出版ステータス出版済み - 2006

All Science Journal Classification (ASJC) codes

  • Animal Science and Zoology

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