Intracerebroventricular injection of vasoactive intestinal peptide and pituitary adenylate cyclase-activating polypeptide inhibits feeding in chicks

Tetsuya Tachibana, Shin Saito, Shozo Tomonaga, Tomo Takagi, Ei Suke Saito, Tim Boswell, Mitsuhiro Furuse

研究成果: Contribution to journalArticle

66 引用 (Scopus)

抜粋

Previous research has indicated an involvement of glucagon superfamily peptides in the regulation of feeding in the domestic chick brain. However the possible roles of vasoactive intestinal peptide (VIP) and pituitary adenylate cyclase-activating polypeptide-38 (PACAP) have not yet been investigated. We therefore examined the effect of intracerebroventricular (ICV) injections of VIP or PACAP on food intake in chicks. ICV injection of both VIP and PACAP significantly inhibited food intake over 4 h at doses ranging from 12 to 188 pmol. Subsequently, we compared the anorexic effect the glucagon superfamily peptides VIP, PACAP, growth hormone-releasing factor (GRF) and glucagon-like peptide-1 (GLP-1) after ICV injection at an equimolar dose (12 pmol). All four peptides significantly inhibited food intake, although the anorexic effects of VIP and PACAP were weaker than those of GRF and GLP-1. These findings support the hypothesis that glucagon superfamily peptides play an important role in the regulation of appetite in the chick brain.

元の言語英語
ページ(範囲)203-206
ページ数4
ジャーナルNeuroscience Letters
339
発行部数3
DOI
出版物ステータス出版済み - 3 27 2003

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)

フィンガープリント Intracerebroventricular injection of vasoactive intestinal peptide and pituitary adenylate cyclase-activating polypeptide inhibits feeding in chicks' の研究トピックを掘り下げます。これらはともに一意のフィンガープリントを構成します。

  • これを引用