TY - JOUR
T1 - Intraductal carcinoma in a surgically resected pancreas with chronic pancreatitis
AU - Mizumoto, Kazuhiro
AU - Tsutsumi, Masahiro
AU - Kitazawa, Shunji
AU - Tsujita, Shigenobu
AU - Nakayama, Masaki
AU - Tsujii, Tadasu
AU - Kanehiro, Hiromichi
AU - Nakajima, Yoshiyuki
AU - Nakano, Hiroshige
AU - Konishi, Yoichi
PY - 1990/12
Y1 - 1990/12
N2 - A 59-yr-old Japanese male presented with epigastralgia. Endoscopic retrograde cholangiopancreatography (ERCP) revealed narrowing of the inferior common bile duct and protein plugs in the main pancreatic duct. He was diagnosed as suffering from chronic pancreatitis with suspicion of a pancreatic head tumor, and a pancreatoduodenectomy was performed. Histologically, a diffuse chronic pancreatitis was evident in the resected pancreas. Although no tumors were seen in the head portion of the pancreas around the inferior common bile duct, an intraductal carcinoma was found in the second branch of Santorini's duct. Precancerous alteration of the duct epithelium, presenting papillary hyperplasia, and atypical hyperplasia were observed in areas continuous with the intraductal carcinoma. Immunohistochemically, carcinoembronic antigen (CEA) was specifically expressed in atypical hyperplasia and intraductal carcinoma, but not in papillary hyperplasia.
AB - A 59-yr-old Japanese male presented with epigastralgia. Endoscopic retrograde cholangiopancreatography (ERCP) revealed narrowing of the inferior common bile duct and protein plugs in the main pancreatic duct. He was diagnosed as suffering from chronic pancreatitis with suspicion of a pancreatic head tumor, and a pancreatoduodenectomy was performed. Histologically, a diffuse chronic pancreatitis was evident in the resected pancreas. Although no tumors were seen in the head portion of the pancreas around the inferior common bile duct, an intraductal carcinoma was found in the second branch of Santorini's duct. Precancerous alteration of the duct epithelium, presenting papillary hyperplasia, and atypical hyperplasia were observed in areas continuous with the intraductal carcinoma. Immunohistochemically, carcinoembronic antigen (CEA) was specifically expressed in atypical hyperplasia and intraductal carcinoma, but not in papillary hyperplasia.
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U2 - 10.1007/BF02924450
DO - 10.1007/BF02924450
M3 - Article
AN - SCOPUS:0025547586
SN - 1941-6628
VL - 7
SP - 279
EP - 285
JO - Journal of Gastrointestinal Cancer
JF - Journal of Gastrointestinal Cancer
IS - 4
ER -