Intraluminal superior vena cava metastasis from adenosquamous carcinoma of the duodenum: A case report

Kotoe Takayoshi, hiroshi ariyama, Shingo Tamura, Shunsuke Yoda, Takeshi Arita, Toshihiro Yamaguchi, Keigo Ozono, Hidetaka Yamamoto, Kyoko Inadomi, Hozumi Kumagai, Mamoru Tanaka, Yuta Okumura, Kosuke Sagara, Kenta Nio, Michitaka Nakano, Shuji Arita, Hitoshi Kusaba, Keita Odashiro, Yoshinao Oda, Koichi AkashiEishi Baba

研究成果: ジャーナルへの寄稿記事

1 引用 (Scopus)

抄録

In 2013, a 76-year-old male with a cardiac pacemaker was diagnosed with adenosquamous carcinoma of the duodenum. Subsequently, a pancreatoduodenectomy and lymph node dissection were performed, and 12 cycles of adjuvant chemotherapy (modified FOLFOX6 regimen), which consisted of fluorouracil, leucovorin and oxaliplatin, were administered via a central venous catheter. At 5 months after the completion of adjuvant chemotherapy, the patient experienced the sudden onset of severe pain at the back right of the ear, edema of the right side of the face and right jugular vein dilatation. Computed tomography (CT) revealed filling defects in the superior vena cava (SVC) and right brachiocephalic vein, indicating catheter-induced venous thrombosis. Although the catheter was removed and anti-coagulation therapy, aspiration of the thrombosis and ballooning dilatation were performed immediately, the patient's symptoms were not ameliorated. Notably, histological examination following thrombus aspiration revealed metastatic cancer cells, and fluorodeoxyglucose-positron emission tomography/CT identified metabolically active nodules in the SVC at locations consistent with the initial duodenal tumors detected by CT and in the first thoracic vertebrae. The tumor thrombus rapidly increased in size and resulted in worsening dyspnea. Subsequently, radiotherapy was performed, followed by chemotherapy, which relieved the systemic symptoms and suppressed the tumor growth. Adenosquamous carcinoma of the duodenum is extremely rare, and to the best of our knowledge, intraluminal SVC metastasis as a result of adenosquamous carcinoma of the duodenum has not been reported previously. The placement of a cardiac pacemaker, central venous catheter and tumor cells possessing high metastatic potential are hypothesized to have contributed to this rare case of metastasis.

元の言語英語
ページ(範囲)605-609
ページ数5
ジャーナルOncology Letters
11
発行部数1
DOI
出版物ステータス出版済み - 1 1 2016

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Adenosquamous Carcinoma
Superior Vena Cava
Duodenum
Neoplasm Metastasis
oxaliplatin
Thrombosis
Central Venous Catheters
Neoplasms
Adjuvant Chemotherapy
Dilatation
Catheters
Tomography
Brachiocephalic Veins
Thoracic Vertebrae
Pancreaticoduodenectomy
Leucovorin
Jugular Veins
Back Pain
Lymph Node Excision
Venous Thrombosis

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

これを引用

Intraluminal superior vena cava metastasis from adenosquamous carcinoma of the duodenum : A case report. / Takayoshi, Kotoe; ariyama, hiroshi; Tamura, Shingo; Yoda, Shunsuke; Arita, Takeshi; Yamaguchi, Toshihiro; Ozono, Keigo; Yamamoto, Hidetaka; Inadomi, Kyoko; Kumagai, Hozumi; Tanaka, Mamoru; Okumura, Yuta; Sagara, Kosuke; Nio, Kenta; Nakano, Michitaka; Arita, Shuji; Kusaba, Hitoshi; Odashiro, Keita; Oda, Yoshinao; Akashi, Koichi; Baba, Eishi.

:: Oncology Letters, 巻 11, 番号 1, 01.01.2016, p. 605-609.

研究成果: ジャーナルへの寄稿記事

Takayoshi, K, ariyama, H, Tamura, S, Yoda, S, Arita, T, Yamaguchi, T, Ozono, K, Yamamoto, H, Inadomi, K, Kumagai, H, Tanaka, M, Okumura, Y, Sagara, K, Nio, K, Nakano, M, Arita, S, Kusaba, H, Odashiro, K, Oda, Y, Akashi, K & Baba, E 2016, 'Intraluminal superior vena cava metastasis from adenosquamous carcinoma of the duodenum: A case report', Oncology Letters, 巻. 11, 番号 1, pp. 605-609. https://doi.org/10.3892/ol.2015.3938
Takayoshi, Kotoe ; ariyama, hiroshi ; Tamura, Shingo ; Yoda, Shunsuke ; Arita, Takeshi ; Yamaguchi, Toshihiro ; Ozono, Keigo ; Yamamoto, Hidetaka ; Inadomi, Kyoko ; Kumagai, Hozumi ; Tanaka, Mamoru ; Okumura, Yuta ; Sagara, Kosuke ; Nio, Kenta ; Nakano, Michitaka ; Arita, Shuji ; Kusaba, Hitoshi ; Odashiro, Keita ; Oda, Yoshinao ; Akashi, Koichi ; Baba, Eishi. / Intraluminal superior vena cava metastasis from adenosquamous carcinoma of the duodenum : A case report. :: Oncology Letters. 2016 ; 巻 11, 番号 1. pp. 605-609.
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abstract = "In 2013, a 76-year-old male with a cardiac pacemaker was diagnosed with adenosquamous carcinoma of the duodenum. Subsequently, a pancreatoduodenectomy and lymph node dissection were performed, and 12 cycles of adjuvant chemotherapy (modified FOLFOX6 regimen), which consisted of fluorouracil, leucovorin and oxaliplatin, were administered via a central venous catheter. At 5 months after the completion of adjuvant chemotherapy, the patient experienced the sudden onset of severe pain at the back right of the ear, edema of the right side of the face and right jugular vein dilatation. Computed tomography (CT) revealed filling defects in the superior vena cava (SVC) and right brachiocephalic vein, indicating catheter-induced venous thrombosis. Although the catheter was removed and anti-coagulation therapy, aspiration of the thrombosis and ballooning dilatation were performed immediately, the patient's symptoms were not ameliorated. Notably, histological examination following thrombus aspiration revealed metastatic cancer cells, and fluorodeoxyglucose-positron emission tomography/CT identified metabolically active nodules in the SVC at locations consistent with the initial duodenal tumors detected by CT and in the first thoracic vertebrae. The tumor thrombus rapidly increased in size and resulted in worsening dyspnea. Subsequently, radiotherapy was performed, followed by chemotherapy, which relieved the systemic symptoms and suppressed the tumor growth. Adenosquamous carcinoma of the duodenum is extremely rare, and to the best of our knowledge, intraluminal SVC metastasis as a result of adenosquamous carcinoma of the duodenum has not been reported previously. The placement of a cardiac pacemaker, central venous catheter and tumor cells possessing high metastatic potential are hypothesized to have contributed to this rare case of metastasis.",
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T1 - Intraluminal superior vena cava metastasis from adenosquamous carcinoma of the duodenum

T2 - A case report

AU - Takayoshi, Kotoe

AU - ariyama, hiroshi

AU - Tamura, Shingo

AU - Yoda, Shunsuke

AU - Arita, Takeshi

AU - Yamaguchi, Toshihiro

AU - Ozono, Keigo

AU - Yamamoto, Hidetaka

AU - Inadomi, Kyoko

AU - Kumagai, Hozumi

AU - Tanaka, Mamoru

AU - Okumura, Yuta

AU - Sagara, Kosuke

AU - Nio, Kenta

AU - Nakano, Michitaka

AU - Arita, Shuji

AU - Kusaba, Hitoshi

AU - Odashiro, Keita

AU - Oda, Yoshinao

AU - Akashi, Koichi

AU - Baba, Eishi

PY - 2016/1/1

Y1 - 2016/1/1

N2 - In 2013, a 76-year-old male with a cardiac pacemaker was diagnosed with adenosquamous carcinoma of the duodenum. Subsequently, a pancreatoduodenectomy and lymph node dissection were performed, and 12 cycles of adjuvant chemotherapy (modified FOLFOX6 regimen), which consisted of fluorouracil, leucovorin and oxaliplatin, were administered via a central venous catheter. At 5 months after the completion of adjuvant chemotherapy, the patient experienced the sudden onset of severe pain at the back right of the ear, edema of the right side of the face and right jugular vein dilatation. Computed tomography (CT) revealed filling defects in the superior vena cava (SVC) and right brachiocephalic vein, indicating catheter-induced venous thrombosis. Although the catheter was removed and anti-coagulation therapy, aspiration of the thrombosis and ballooning dilatation were performed immediately, the patient's symptoms were not ameliorated. Notably, histological examination following thrombus aspiration revealed metastatic cancer cells, and fluorodeoxyglucose-positron emission tomography/CT identified metabolically active nodules in the SVC at locations consistent with the initial duodenal tumors detected by CT and in the first thoracic vertebrae. The tumor thrombus rapidly increased in size and resulted in worsening dyspnea. Subsequently, radiotherapy was performed, followed by chemotherapy, which relieved the systemic symptoms and suppressed the tumor growth. Adenosquamous carcinoma of the duodenum is extremely rare, and to the best of our knowledge, intraluminal SVC metastasis as a result of adenosquamous carcinoma of the duodenum has not been reported previously. The placement of a cardiac pacemaker, central venous catheter and tumor cells possessing high metastatic potential are hypothesized to have contributed to this rare case of metastasis.

AB - In 2013, a 76-year-old male with a cardiac pacemaker was diagnosed with adenosquamous carcinoma of the duodenum. Subsequently, a pancreatoduodenectomy and lymph node dissection were performed, and 12 cycles of adjuvant chemotherapy (modified FOLFOX6 regimen), which consisted of fluorouracil, leucovorin and oxaliplatin, were administered via a central venous catheter. At 5 months after the completion of adjuvant chemotherapy, the patient experienced the sudden onset of severe pain at the back right of the ear, edema of the right side of the face and right jugular vein dilatation. Computed tomography (CT) revealed filling defects in the superior vena cava (SVC) and right brachiocephalic vein, indicating catheter-induced venous thrombosis. Although the catheter was removed and anti-coagulation therapy, aspiration of the thrombosis and ballooning dilatation were performed immediately, the patient's symptoms were not ameliorated. Notably, histological examination following thrombus aspiration revealed metastatic cancer cells, and fluorodeoxyglucose-positron emission tomography/CT identified metabolically active nodules in the SVC at locations consistent with the initial duodenal tumors detected by CT and in the first thoracic vertebrae. The tumor thrombus rapidly increased in size and resulted in worsening dyspnea. Subsequently, radiotherapy was performed, followed by chemotherapy, which relieved the systemic symptoms and suppressed the tumor growth. Adenosquamous carcinoma of the duodenum is extremely rare, and to the best of our knowledge, intraluminal SVC metastasis as a result of adenosquamous carcinoma of the duodenum has not been reported previously. The placement of a cardiac pacemaker, central venous catheter and tumor cells possessing high metastatic potential are hypothesized to have contributed to this rare case of metastasis.

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