Intrastriatal grafts of fetal ventral mesencephalon improve allodynia-like withdrawal response to mechanical stimulation in a rat model of Parkinson's disease

Ryuichiro Takeda, Yasushi Ishida, Kosuke Ebihara, Hiroshi Abe, Hisae Matsuo, Tetsuya Ikeda, Go Koganemaru, Aki Kuramashi, Hideki Funahashi, Yasuhiro Magata, Keiichi Kawai, Toshikazu Nishimori

研究成果: Contribution to journalArticle査読

8 被引用数 (Scopus)

抄録

We previously reported that a unilateral 6-hydroxydopamine (6-OHDA) rat model of Parkinson's disease showed allodynia-like withdrawal response to mechanical stimulation of the ipsilateral side of the rat hindpaw. The goal of this study was to investigate the effect of intrastriatal grafts of fetal ventral mesencephalon (VM) on the withdrawal response in 6-OHDA rats. The withdrawal threshold in response to the mechanical stimulation of the rat hindpaw was measured using von Frey filaments. In the ipsilateral side of the 6-OHDA lesions, the withdrawal threshold in response to mechanical stimulation significantly increased in 6-OHDA rats with VM grafts compared with those with sham grafts, but did not change in the contralateral side at 5 weeks after transplantation. The present results suggest that the intrastriatal grafts of fetal VM may relieve pain sensation induced by mechanical stimulation in 6-OHDA rats.

本文言語英語
ページ(範囲)19-23
ページ数5
ジャーナルNeuroscience Letters
573
DOI
出版ステータス出版済み - 6 24 2014
外部発表はい

All Science Journal Classification (ASJC) codes

  • 神経科学(全般)

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