Inverse associations of serum bilirubin with high sensitivity C-reactive protein, glycated hemoglobin, and prevalence of type 2 diabetes in middle-aged and elderly Japanese men and women

Keizo Ohnaka, Suminori Kono, Toyoshi Inoguchi, Guang Yin, Makiko Morita, Masahiro Adachi, Hisaya Kawate, Ryoichi Takayanagi

研究成果: ジャーナルへの寄稿記事

61 引用 (Scopus)

抄録

Aim: The aim of this study was to examine the association of serum bilirubin, an endogenous antioxidant, with serum high sensitivity C-reactive protein (hs-CRP) level, HbA1c, and the prevalence of type 2 diabetes in middle-aged and elderly Japanese men and women (n = 12,400). Methods: Analysis of covariance and logistic regression analysis were used to estimate geometric means of hs-CRP and HbA1c and odds ratios of prevalent diabetes according to bilirubin concentrations, respectively, with statistical adjustment for behavioral factors and liver enzymes. Results: Geometric means of hs-CRP and HbA1c were progressively lower with increasing concentrations of serum bilirubin in men and women each. An inverse association between serum bilirubin and HbA1c was slightly attenuated after adjustment for hs-CRP, but still remained highly significant (trend P = 0.0004 in men and trend P = 10-5 in women). Multivariate-adjusted odds ratios of prevalent diabetes for the lowest to highest quintiles of serum total bilirubin were 1.00, 1.00, 0.73, 0.80, and 0.73 (trend P = 0.002), without adjustment for hs-CRP, and 1.00, 1.04, 0.76, 0.86, and 0.79 (trend P = 0.01), with adjustment for hs-CRP. Conclusions: Higher concentrations of serum bilirubin probably confer protection against the development of type 2 diabetes.

元の言語英語
ページ(範囲)103-110
ページ数8
ジャーナルDiabetes Research and Clinical Practice
88
発行部数1
DOI
出版物ステータス出版済み - 4 1 2010

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Glycosylated Hemoglobin A
Bilirubin
C-Reactive Protein
Type 2 Diabetes Mellitus
Serum
Odds Ratio
Antioxidants
Logistic Models
Regression Analysis
Liver
Enzymes

All Science Journal Classification (ASJC) codes

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

これを引用

Inverse associations of serum bilirubin with high sensitivity C-reactive protein, glycated hemoglobin, and prevalence of type 2 diabetes in middle-aged and elderly Japanese men and women. / Ohnaka, Keizo; Kono, Suminori; Inoguchi, Toyoshi; Yin, Guang; Morita, Makiko; Adachi, Masahiro; Kawate, Hisaya; Takayanagi, Ryoichi.

:: Diabetes Research and Clinical Practice, 巻 88, 番号 1, 01.04.2010, p. 103-110.

研究成果: ジャーナルへの寄稿記事

Ohnaka, Keizo ; Kono, Suminori ; Inoguchi, Toyoshi ; Yin, Guang ; Morita, Makiko ; Adachi, Masahiro ; Kawate, Hisaya ; Takayanagi, Ryoichi. / Inverse associations of serum bilirubin with high sensitivity C-reactive protein, glycated hemoglobin, and prevalence of type 2 diabetes in middle-aged and elderly Japanese men and women. :: Diabetes Research and Clinical Practice. 2010 ; 巻 88, 番号 1. pp. 103-110.
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abstract = "Aim: The aim of this study was to examine the association of serum bilirubin, an endogenous antioxidant, with serum high sensitivity C-reactive protein (hs-CRP) level, HbA1c, and the prevalence of type 2 diabetes in middle-aged and elderly Japanese men and women (n = 12,400). Methods: Analysis of covariance and logistic regression analysis were used to estimate geometric means of hs-CRP and HbA1c and odds ratios of prevalent diabetes according to bilirubin concentrations, respectively, with statistical adjustment for behavioral factors and liver enzymes. Results: Geometric means of hs-CRP and HbA1c were progressively lower with increasing concentrations of serum bilirubin in men and women each. An inverse association between serum bilirubin and HbA1c was slightly attenuated after adjustment for hs-CRP, but still remained highly significant (trend P = 0.0004 in men and trend P = 10-5 in women). Multivariate-adjusted odds ratios of prevalent diabetes for the lowest to highest quintiles of serum total bilirubin were 1.00, 1.00, 0.73, 0.80, and 0.73 (trend P = 0.002), without adjustment for hs-CRP, and 1.00, 1.04, 0.76, 0.86, and 0.79 (trend P = 0.01), with adjustment for hs-CRP. Conclusions: Higher concentrations of serum bilirubin probably confer protection against the development of type 2 diabetes.",
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AU - Inoguchi, Toyoshi

AU - Yin, Guang

AU - Morita, Makiko

AU - Adachi, Masahiro

AU - Kawate, Hisaya

AU - Takayanagi, Ryoichi

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