This study investigates the applicability of Maisotsenko cycle evaporative cooling system for climatic conditions of Multan region (Pakistan). The study also provides comparison of (Maisotsenko-cycle) M-Cycle based system with other evaporative cooling systems. An experimental system of M-Cycle has been setup and experiments are conducted for various ambient air conditions. The data has been analyzed, and based on the analyses the performance of the proposed M-cycle system has been investigated for summer (April to September) climatic conditions of Multan region (Pakistan). It has been found that the proposed system can provide the useful air-conditioning effect for Multan climate conditions provided that the ambient air relative humidity does not exceed 60%. The system's applicability is found limited in humid conditions, which is due to nature of M-cycle operation.