Invitro cell viability and antibacterial activity of novel bismuth (V) complex

Sandeep Garg, Pankaj Attri, Kameshwar Sharma, Rajeev Ranjan, Parshuram Mishra

研究成果: Contribution to journalArticle査読

抄録

Bismuth (V) was incorporated in chloramphenicol and streptomycin keeping in view of finding new antibiotics. Formed complex was evaluated for their antibacterial and cell viability activity in mice. Murine peritoneal macrophage cell lines RAW 264.7 were used for in vitro antibacterial and cytotoxicty studies of various synthesized compounds. Bactericidal activity was assessed by Minimum inhibitory concentrations (MIC) of various compounds against different bacterial strains. Antibacterial activity of T-IV was found highest among all treatments given followed by T-III. Metal-ligand administered group showed comparatively higher in vitro cell viability than standard drug streptomycin. It was concluded that metal drug complex may have better antibiotic activity than parent antibiotics alone.

本文言語英語
ページ(範囲)1685-1691
ページ数7
ジャーナルInternational Journal of PharmTech Research
1
4
出版ステータス出版済み - 10 1 2009
外部発表はい

All Science Journal Classification (ASJC) codes

  • 薬理学
  • 薬科学

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