Bismuth (V) was incorporated in chloramphenicol and streptomycin keeping in view of finding new antibiotics. Formed complex was evaluated for their antibacterial and cell viability activity in mice. Murine peritoneal macrophage cell lines RAW 264.7 were used for in vitro antibacterial and cytotoxicty studies of various synthesized compounds. Bactericidal activity was assessed by Minimum inhibitory concentrations (MIC) of various compounds against different bacterial strains. Antibacterial activity of T-IV was found highest among all treatments given followed by T-III. Metal-ligand administered group showed comparatively higher in vitro cell viability than standard drug streptomycin. It was concluded that metal drug complex may have better antibiotic activity than parent antibiotics alone.
|ジャーナル||International Journal of PharmTech Research|
|出版ステータス||出版済み - 10 1 2009|
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