Involvement of angiotensin II in water intake of genetically polydipsic mice

T. Katafuchi, Y. Hattori, I. Nagatomo, K. Koizumi, E. Silverstein

研究成果: ジャーナルへの寄稿記事

18 引用 (Scopus)

抄録

The involvement of angiotensin II (ANG II) in the genetic polydipsia of the STR/N strain of mice was investigated. Daily water intake of the polydipsic inbred STR/N of both sexes ranged between five and eight times that of nonpolydipsic controls: STR/1N, a mutant of the STR/N, and Swiss-Webster (S/W) mice. Nevertheless the diurnal pattern of drinking was maintained in the STR/N. There was no difference in daily food intake, arterial blood pressure, and plasma renin activity among the three groups. Drinking responses to 48 h of water deprivation were not significantly different between the polydipsic mice and their control groups. Captopril, an angiotensin I converting-enzyme inhibitor, injected subcutaneously just before the dark period, reduced drinking for 6 h in the polydipsic strain only. Food intake of all three groups of mice was not affected. Similarly the ANG II antagonist saralasin, [Sar1,-Ile8]ANG II, injected into the lateral cerebroventricle just before the dark period, significantly reduced water intake for 6 h after injection in the polydipsic mice only. Intracerebroventricular injection of ANG II increased drinking in the nondeprived controls but not in the polydipsic mice. These findings suggest that the polydipsia in the STR/N mice may involve, at least in part, the ANG II system in the brain.

元の言語英語
ページ(範囲)R1152-R1158
ジャーナルAmerican Journal of Physiology - Regulatory Integrative and Comparative Physiology
260
発行部数6 29-6
出版物ステータス出版済み - 1 1 1991

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Angiotensin II
Drinking
Polydipsia
Eating
Saralasin
Water Deprivation
Injections
Captopril
Angiotensin-Converting Enzyme Inhibitors
Renin
Arterial Pressure
Control Groups
Brain

All Science Journal Classification (ASJC) codes

  • Physiology
  • Physiology (medical)

これを引用

Katafuchi, T., Hattori, Y., Nagatomo, I., Koizumi, K., & Silverstein, E. (1991). Involvement of angiotensin II in water intake of genetically polydipsic mice. American Journal of Physiology - Regulatory Integrative and Comparative Physiology, 260(6 29-6), R1152-R1158.

Involvement of angiotensin II in water intake of genetically polydipsic mice. / Katafuchi, T.; Hattori, Y.; Nagatomo, I.; Koizumi, K.; Silverstein, E.

:: American Journal of Physiology - Regulatory Integrative and Comparative Physiology, 巻 260, 番号 6 29-6, 01.01.1991, p. R1152-R1158.

研究成果: ジャーナルへの寄稿記事

Katafuchi, T, Hattori, Y, Nagatomo, I, Koizumi, K & Silverstein, E 1991, 'Involvement of angiotensin II in water intake of genetically polydipsic mice', American Journal of Physiology - Regulatory Integrative and Comparative Physiology, 巻. 260, 番号 6 29-6, pp. R1152-R1158.
Katafuchi, T. ; Hattori, Y. ; Nagatomo, I. ; Koizumi, K. ; Silverstein, E. / Involvement of angiotensin II in water intake of genetically polydipsic mice. :: American Journal of Physiology - Regulatory Integrative and Comparative Physiology. 1991 ; 巻 260, 番号 6 29-6. pp. R1152-R1158.
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