The effects of intracerebroventricular (ICV) injection of chicken gastrin and cholecystokinin (CCK) on food intake were compared in the neonatal chick. In Experiment 1, the effect of 131 pmol of chicken gastrin (36 amino acid residues) on food intake was compared with 66 and 131 pmol of CCK-8S over 2h. Chicken gastrin strongly inhibited food intake, but both levels of CCK-8S did not. The similar effect of 131 pmol chicken gastrin was obtained by 262 pmol CCK-8S at lh after ICV injection in Experiment 2. This suppressive effect of chicken gastrin continued over 2h after ICV injection, though the effect of CCK-8S had disappeared by 2h. In Experiment 3, the effects of 131 pmol ofCCK-8S, CCK-33S and chicken gastrin were compared. The effect ofCCK-8S was weak, but CCK-33S and chicken gastrin similarly and strongly inhibited food intake of chicks. These results suggested that the suppressive effect of food intake of gastrin/CCK family may be dependent upon the length of amino acid sequence.
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