Involvement of chondroitin 6-sulfation in temporal lobe epilepsy

Noriko Yutsudo, Hiroshi Kitagawa

研究成果: Contribution to journalArticle査読

22 被引用数 (Scopus)

抄録

Chondroitin sulfate proteoglycans (CSPGs) are predominant components of the extracellular matrix in the central nervous system (CNS). Previously, we found an increase in the 4-sulfation/6-sulfation (4S/6S) ratio of CSPGs is required for perineuronal net (PNN) formation and results in functional maturation of parvalbumin-expressing interneurons (PV cells) and termination of the critical period in the visual cortex. Here, we report that chondroitin 6-sulfation and chondroitin 6-sulfation-enriched PNNs increased in the mouse cerebral cortex and hippocampus after kainic acid (KA) treatment; simultaneously, chondroitin 4-sulfation-enriched PNNs and the 4S/6S ratio decreased. Furthermore, chondroitin 6-O-sulfotransferase-1 (C6ST-1) transgenic (TG) mice, which overexpress chondroitin 6-sulfated chains and have a decreased 4S/6S ratio, were more susceptible to KA-induced seizures than wild-type mice. These results suggested that chondroitin 6-sulfation is relevant to epilepsy most probably because of dysregulated PNN formation and PV cell maturation.

本文言語英語
ページ(範囲)126-133
ページ数8
ジャーナルExperimental Neurology
274
DOI
出版ステータス出版済み - 12 1 2015
外部発表はい

All Science Journal Classification (ASJC) codes

  • 神経学
  • 発達神経科学

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