Involvement of intracellular cAMP in epirubicin-induced vascular endothelial cell injury

Takaaki Yamada, Mitsuyo Ueda, Nobuaki Egashira, Nina Zukeyama, Jun Kuwahara, Satohiro Masuda

研究成果: ジャーナルへの寄稿記事

5 引用 (Scopus)

抄録

We investigated the involvement of intracellular cAMP in endothelial cell injury induced by epirubicin. Epirubicin-induced decrease in cell viability and increase in caspase-3/7 activity were reversed by a cAMP analog dibutyryl cAMP (DBcAMP) or an activator of adenylate cyclase forskolin concomitant with a phosphodiesterase inhibitor 3-isobutyl-1-methylxanthine. Moreover, epirubicin-induced elevation of lipid peroxide levels was attenuated by DBcAMP. Interestingly, the exposure of epirubicin decreased intracellular cAMP levels before the onset of epirubicin-induced production of lipid peroxidation. These results suggest that intracellular cAMP plays an important role in epirubicin-induced endothelial cell injury.

元の言語英語
ページ(範囲)33-37
ページ数5
ジャーナルJournal of Pharmacological Sciences
130
発行部数1
DOI
出版物ステータス出版済み - 1 1 2016

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Epirubicin
Endothelial Cells
Wounds and Injuries
Caspase 7
1-Methyl-3-isobutylxanthine
Phosphodiesterase Inhibitors
Lipid Peroxides
Colforsin
Adenylyl Cyclases
Caspase 3
Lipid Peroxidation
Cell Survival

All Science Journal Classification (ASJC) codes

  • Molecular Medicine
  • Pharmacology

これを引用

Involvement of intracellular cAMP in epirubicin-induced vascular endothelial cell injury. / Yamada, Takaaki; Ueda, Mitsuyo; Egashira, Nobuaki; Zukeyama, Nina; Kuwahara, Jun; Masuda, Satohiro.

:: Journal of Pharmacological Sciences, 巻 130, 番号 1, 01.01.2016, p. 33-37.

研究成果: ジャーナルへの寄稿記事

Yamada, Takaaki ; Ueda, Mitsuyo ; Egashira, Nobuaki ; Zukeyama, Nina ; Kuwahara, Jun ; Masuda, Satohiro. / Involvement of intracellular cAMP in epirubicin-induced vascular endothelial cell injury. :: Journal of Pharmacological Sciences. 2016 ; 巻 130, 番号 1. pp. 33-37.
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