Involvement of opioid system in cognitive deficits induced by Δ 9-tetrahydrocannabinol in rats

Nobuaki Egashira, Naomi Manome, Kenichi Mishima, Katsunori Iwasaki, Ryozo Oishi, Michihiro Fujiwara

研究成果: ジャーナルへの寄稿記事

7 引用 (Scopus)

抄録

Rationale: Cannabis is a widely used illicit substance. Δ 9-Tetrahydrocannabinol (THC), the major psychoactive component of cannabis, is known to induce cognitive deficits that closely resemble the impairment observed in schizophrenic patients. We previously reported that THC (6 mg/kg) impairs spatial memory in the eight-arm radial maze, and that this memory disturbance was reversed by the cannabinoid CB 1 receptor antagonist rimonabant (0.1 mg/kg), suggesting that the effect of THC is mediated through cannabinoid CB 1 receptors. Objectives: The present study was designed to examine the possible involvement of opioid receptors in the THC-induced impairment of spatial memory. Methods: The effects of treatment with the nonselective opioid receptor antagonist naloxone (0.3 and 1 mg/kg), the μ-opioid receptor antagonist β-funaltrexamine (0.3 and 1 mg/kg), the δ-opioid receptor antagonist naltrindole (1 and 3 mg/kg), and the κ-opioid receptor antagonist nor-binaltorphimine (0.03 and 0.1 mg/kg) on the impairment of spatial memory induced by THC were evaluated using the eight-arm radial maze. Results: The nonselective opioid receptor antagonist naloxone, the μ-opioid receptor antagonist β-funaltrexamine, and the κ-opioid receptor antagonist nor-binaltorphimine, but not the δ-opioid receptor antagonist naltrindole, attenuated THC-induced cognitive deficits, suggesting an involvement of μ- and κ-opioid receptors in this behavioral response. Conclusions: These results demonstrate that the endogenous opioid system is involved in the regulation of the acute short-term and working memory deficits induced by cannabis.

元の言語英語
ページ(範囲)1111-1118
ページ数8
ジャーナルPsychopharmacology
219
発行部数4
DOI
出版物ステータス出版済み - 2 1 2012

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Dronabinol
Narcotic Antagonists
Opioid Analgesics
naltrindole
Cannabis
rimonabant
Cannabinoids
Opioid Receptors
Short-Term Memory
Memory Disorders
Naloxone

All Science Journal Classification (ASJC) codes

  • Pharmacology

これを引用

Involvement of opioid system in cognitive deficits induced by Δ 9-tetrahydrocannabinol in rats. / Egashira, Nobuaki; Manome, Naomi; Mishima, Kenichi; Iwasaki, Katsunori; Oishi, Ryozo; Fujiwara, Michihiro.

:: Psychopharmacology, 巻 219, 番号 4, 01.02.2012, p. 1111-1118.

研究成果: ジャーナルへの寄稿記事

Egashira, Nobuaki ; Manome, Naomi ; Mishima, Kenichi ; Iwasaki, Katsunori ; Oishi, Ryozo ; Fujiwara, Michihiro. / Involvement of opioid system in cognitive deficits induced by Δ 9-tetrahydrocannabinol in rats. :: Psychopharmacology. 2012 ; 巻 219, 番号 4. pp. 1111-1118.
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abstract = "Rationale: Cannabis is a widely used illicit substance. Δ 9-Tetrahydrocannabinol (THC), the major psychoactive component of cannabis, is known to induce cognitive deficits that closely resemble the impairment observed in schizophrenic patients. We previously reported that THC (6 mg/kg) impairs spatial memory in the eight-arm radial maze, and that this memory disturbance was reversed by the cannabinoid CB 1 receptor antagonist rimonabant (0.1 mg/kg), suggesting that the effect of THC is mediated through cannabinoid CB 1 receptors. Objectives: The present study was designed to examine the possible involvement of opioid receptors in the THC-induced impairment of spatial memory. Methods: The effects of treatment with the nonselective opioid receptor antagonist naloxone (0.3 and 1 mg/kg), the μ-opioid receptor antagonist β-funaltrexamine (0.3 and 1 mg/kg), the δ-opioid receptor antagonist naltrindole (1 and 3 mg/kg), and the κ-opioid receptor antagonist nor-binaltorphimine (0.03 and 0.1 mg/kg) on the impairment of spatial memory induced by THC were evaluated using the eight-arm radial maze. Results: The nonselective opioid receptor antagonist naloxone, the μ-opioid receptor antagonist β-funaltrexamine, and the κ-opioid receptor antagonist nor-binaltorphimine, but not the δ-opioid receptor antagonist naltrindole, attenuated THC-induced cognitive deficits, suggesting an involvement of μ- and κ-opioid receptors in this behavioral response. Conclusions: These results demonstrate that the endogenous opioid system is involved in the regulation of the acute short-term and working memory deficits induced by cannabis.",
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AU - Iwasaki, Katsunori

AU - Oishi, Ryozo

AU - Fujiwara, Michihiro

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AB - Rationale: Cannabis is a widely used illicit substance. Δ 9-Tetrahydrocannabinol (THC), the major psychoactive component of cannabis, is known to induce cognitive deficits that closely resemble the impairment observed in schizophrenic patients. We previously reported that THC (6 mg/kg) impairs spatial memory in the eight-arm radial maze, and that this memory disturbance was reversed by the cannabinoid CB 1 receptor antagonist rimonabant (0.1 mg/kg), suggesting that the effect of THC is mediated through cannabinoid CB 1 receptors. Objectives: The present study was designed to examine the possible involvement of opioid receptors in the THC-induced impairment of spatial memory. Methods: The effects of treatment with the nonselective opioid receptor antagonist naloxone (0.3 and 1 mg/kg), the μ-opioid receptor antagonist β-funaltrexamine (0.3 and 1 mg/kg), the δ-opioid receptor antagonist naltrindole (1 and 3 mg/kg), and the κ-opioid receptor antagonist nor-binaltorphimine (0.03 and 0.1 mg/kg) on the impairment of spatial memory induced by THC were evaluated using the eight-arm radial maze. Results: The nonselective opioid receptor antagonist naloxone, the μ-opioid receptor antagonist β-funaltrexamine, and the κ-opioid receptor antagonist nor-binaltorphimine, but not the δ-opioid receptor antagonist naltrindole, attenuated THC-induced cognitive deficits, suggesting an involvement of μ- and κ-opioid receptors in this behavioral response. Conclusions: These results demonstrate that the endogenous opioid system is involved in the regulation of the acute short-term and working memory deficits induced by cannabis.

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