A forced swimming test proposed by Porsolt1) is a useful method for screening antidepressants. To evaluate drug effects more objectively, vibration of the walls of a water tank caused by the escape behavior of the rat was recorded. Imipramine (IMI) increased the number of vibration and this effect was observed in the medial amygdala lesioned rat but not in the central or basolateral amygdala le-sioned rat. The present result suggests that the medial amygdala is an important site of action of IMI.
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