Iodinated silica/porphyrin hybrid nanoparticles for X-ray computed tomography/fluorescence dual-modal imaging of tumors

Koichiro Hayashi, Sakamoto Wataru, Toshinobu Yogo

研究成果: ジャーナルへの寄稿記事

4 引用 (Scopus)

抄録

Silica nanoparticles containing covalently linked iodine and a near-infrared (NIR) fluorescence dye, namely porphyrin, have been synthesized through a one-pot sol-gel reaction. These particles are called iodinated silica/porphyrin hybrid nanoparticles (ISP HNPs). The ISP HNPs have both high X-ray absorption coefficient and NIR fluorescence. The ISP HNPs modified with folic acid (FA) and polyethylene glycol (PEG), denoted as FA-PEG-ISP HNPs, enabled the successful visualization of tumors in mice by both X-ray computed tomography (CT) and fluorescence imaging (FI). Thus, the FA-PEG-ISP HNPs are useful as contrast agents or probes for CT/FI dual-modal imaging.

元の言語英語
ページ(範囲)429-434
ページ数6
ジャーナルJournal of Asian Ceramic Societies
2
発行部数4
DOI
出版物ステータス出版済み - 12 1 2014
外部発表Yes

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Porphyrins
Silicon Dioxide
Tomography
Tumors
Fluorescence
Silica
Nanoparticles
Imaging techniques
X rays
Folic Acid
Polyethylene glycols
Acids
Infrared radiation
X ray absorption
Iodine
Contrast Media
Particles (particulate matter)
Sol-gels
Coloring Agents
Visualization

All Science Journal Classification (ASJC) codes

  • Ceramics and Composites

これを引用

Iodinated silica/porphyrin hybrid nanoparticles for X-ray computed tomography/fluorescence dual-modal imaging of tumors. / Hayashi, Koichiro; Wataru, Sakamoto; Yogo, Toshinobu.

:: Journal of Asian Ceramic Societies, 巻 2, 番号 4, 01.12.2014, p. 429-434.

研究成果: ジャーナルへの寄稿記事

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