Iridium-Catalyzed C(sp3)−H Addition of Methyl Ethers across Intramolecular Carbon–Carbon Double Bonds Giving 2,3-Dihydrobenzofurans

Toshimichi Ohmura, Satoshi Kusaka, Takeru Torigoe, Michinori Suginome

研究成果: Contribution to journalArticle査読

6 被引用数 (Scopus)

抄録

Intramolecular addition of an O-methyl C(sp3)−H bond across a carbon-carbon double bond occurs in the iridium-catalyzed reaction of methyl 2-(propen-2-yl)phenyl ethers. The Ir/(S)-DTBM-SEGPHOS catalyst promotes the reaction efficiently in toluene at 110–135 °C to afford 3,3-dimethyl-2,3-dihydrobenzofurans. Enantioselective C(sp3)−H addition is achieved in the reaction of methyl 2-(1-siloxyethenyl)phenyl ethers, affording enantioenriched 3-hydroxy-2,3-dihydrobenzofuran derivatives with up to 96% ee. (Figure presented.).

本文言語英語
ページ(範囲)4448-4453
ページ数6
ジャーナルAdvanced Synthesis and Catalysis
361
19
DOI
出版ステータス出版済み - 10 8 2019
外部発表はい

All Science Journal Classification (ASJC) codes

  • 触媒
  • 有機化学

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