Irinotecan-based combination chemotherapy for metastatic small intestinal adenocarcinoma

Yoshihiro Shibata, Eishi Baba, hiroshi ariyama, Shuji Arita, Taichi Isobe, Hitoshi Kusaba, Kenji Mitsugi, Shuji Nakano, Koichi Akashi

研究成果: ジャーナルへの寄稿記事

1 引用 (Scopus)

抄録

Metastatic small intestinal adenocarcinoma (SIA) is rare among digestive tract malignancies, and a standard therapy has yet to be established. The present study described a patient who was treated with irinotecan-based chemotherapy. A 67-year-old woman with a long history of anemia was diagnosed as having SIA using small bowel endoscopy. Tumor invasion of the mesentery and multiple metastases to the lungs and peritoneal lymph nodes were detected. Nine courses of chemotherapy, each consisting of bolus infusion of 5-fluorouracil at 500 mg/m2, plus infusion of irinotecan at 100 mg/m2 with l-leucovorin at 20 mg/m2 on days 1, 8 and 15, were administered at 4-weekly intervals postoperatively. After two courses, the metastatic nodules in the lungs showed a decrease in number and size, and this response continued for over 6 months. Adverse events were manageable during this period. The patient succumbed to the disease 12 months after the initial diagnosis. The present results therefore suggest that irinotecan-based chemotherapy is a potential treatment for metastatic SIA.

元の言語英語
ページ(範囲)423-426
ページ数4
ジャーナルOncology Letters
1
発行部数3
DOI
出版物ステータス出版済み - 5 1 2010

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irinotecan
Combination Drug Therapy
Adenocarcinoma
Drug Therapy
Lung
Mesentery
Leucovorin
Fluorouracil
Endoscopy
Gastrointestinal Tract
Anemia
Neoplasms
Lymph Nodes
Neoplasm Metastasis
Therapeutics

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

これを引用

Irinotecan-based combination chemotherapy for metastatic small intestinal adenocarcinoma. / Shibata, Yoshihiro; Baba, Eishi; ariyama, hiroshi; Arita, Shuji; Isobe, Taichi; Kusaba, Hitoshi; Mitsugi, Kenji; Nakano, Shuji; Akashi, Koichi.

:: Oncology Letters, 巻 1, 番号 3, 01.05.2010, p. 423-426.

研究成果: ジャーナルへの寄稿記事

Shibata, Yoshihiro ; Baba, Eishi ; ariyama, hiroshi ; Arita, Shuji ; Isobe, Taichi ; Kusaba, Hitoshi ; Mitsugi, Kenji ; Nakano, Shuji ; Akashi, Koichi. / Irinotecan-based combination chemotherapy for metastatic small intestinal adenocarcinoma. :: Oncology Letters. 2010 ; 巻 1, 番号 3. pp. 423-426.
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AU - Baba, Eishi

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AU - Arita, Shuji

AU - Isobe, Taichi

AU - Kusaba, Hitoshi

AU - Mitsugi, Kenji

AU - Nakano, Shuji

AU - Akashi, Koichi

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