Irreplaceability of neuronal ensembles after memory allocation

研究成果: Contribution to journalArticle査読

26 被引用数 (Scopus)

抄録

Lesion studies suggest that an alternative system can compensate for damage to the primary region employed when animals acquire a memory. However, it is unclear whether functional compensation occurs at the cellular ensemble level. Here, we inhibited the activities of a specific subset of neurons activated during initial learning by utilizing a transgenic mouse that expresses tetanus toxin (TeNT) under the control of the c-fos promoter. Notably, suppression interfered with relearning while sparing the ability to acquire and express fear memory for a distinct context. These results suggest that the activity of the initial ensemble is preferentially dedicated to the same learning and that it is not replaceable once it is allocated. Our results provide substantial insights into the machinery underlying how the brain allocates individual memories todiscrete neuronal ensembles and how it ensures that repetitive learning strengthens memory by reactivating the same neuronal ensembles.

本文言語英語
ページ(範囲)351-357
ページ数7
ジャーナルCell Reports
11
3
DOI
出版ステータス出版済み - 4 21 2015
外部発表はい

All Science Journal Classification (ASJC) codes

  • 生化学、遺伝学、分子生物学(全般)

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