Isolation and structure of a GD3-type ganglioside molecular species possessing neuritogenic activity from the starfish Luidia maculata

Satoshi Kawatake, Masanori Inagaki, Ryuichi Isobe, Tomofumi Miyamoto, Ryuichi Higuchi

研究成果: Contribution to journalArticle査読

12 被引用数 (Scopus)

抄録

A GD3-type ganglioside molecular species, LMG-4 (1), has been obtained from the polar lipid fraction of the chloroform/methanol extract of the starfish Luidia maculata. The structure of this ganglioside has been determined on the basis of chemical and spectroscopic evidence to be 1-O-[(N-acetyl- α-D-neuraminosyl)-(2→8)-(N-acetyl-α-D-neuraminosyl)-(2→3) -β-D-galactopyranosyl-(1→4)-β-D-glucopyranosyl]-ceramide. The ceramide moiety was composed of heterogeneous 2-hydroxy fatty acid and phytosphingosine units. This is the first report on the isolation and structure elucidation of GD3-type ganglioside from echinoderms. Moreover, 1 exhibited neuritogenic activity toward the rat pheochromocytoma PC12 cells in the presence of nerve growth factor.

本文言語英語
ページ(範囲)1002-1004
ページ数3
ジャーナルChemical and Pharmaceutical Bulletin
52
8
DOI
出版ステータス出版済み - 8 1 2004

All Science Journal Classification (ASJC) codes

  • 化学 (全般)
  • 創薬

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「Isolation and structure of a GD<sub>3</sub>-type ganglioside molecular species possessing neuritogenic activity from the starfish Luidia maculata」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

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