抄録
A GD3-type ganglioside molecular species, LMG-4 (1), has been obtained from the polar lipid fraction of the chloroform/methanol extract of the starfish Luidia maculata. The structure of this ganglioside has been determined on the basis of chemical and spectroscopic evidence to be 1-O-[(N-acetyl- α-D-neuraminosyl)-(2→8)-(N-acetyl-α-D-neuraminosyl)-(2→3) -β-D-galactopyranosyl-(1→4)-β-D-glucopyranosyl]-ceramide. The ceramide moiety was composed of heterogeneous 2-hydroxy fatty acid and phytosphingosine units. This is the first report on the isolation and structure elucidation of GD3-type ganglioside from echinoderms. Moreover, 1 exhibited neuritogenic activity toward the rat pheochromocytoma PC12 cells in the presence of nerve growth factor.
本文言語 | 英語 |
---|---|
ページ(範囲) | 1002-1004 |
ページ数 | 3 |
ジャーナル | Chemical and Pharmaceutical Bulletin |
巻 | 52 |
号 | 8 |
DOI | |
出版ステータス | 出版済み - 8月 1 2004 |
!!!All Science Journal Classification (ASJC) codes
- 化学 (全般)
- 創薬