TY - JOUR
T1 - Isolation of new secondary metabolites from gorgonian soft coral Heteroxenia fuscescens collected from Red Sea
AU - Abdelkarem, Fahd M.
AU - Desoky, Ezz Eldin K.
AU - Nafady, Alaa M.
AU - Allam, Ahmed E.
AU - Mahdy, Aldoushy
AU - Nagata, Maki
AU - Miyamoto, Tomofumi
AU - Shimizu, Kuniyoshi
N1 - Funding Information:
The Egyptian ministry of higher education is acknowledged for the fellowship support to Fahd M. Abdelkarem.
Publisher Copyright:
© 2020
Copyright:
Copyright 2020 Elsevier B.V., All rights reserved.
PY - 2020/4
Y1 - 2020/4
N2 - Further chemical study of the crude extract of the soft coral Heteroxenia fuscescens (Fam., Xeniidea), led to isolation of two new sterols, Heterofuscesterols A (1) and B (2), a sterol isolated for the first time from natural sources, 3β,5α,6β-trihydroxyandrosta-17-one (3), along with one new hydroperoxy sesquiterpene, Heterofusceterpene A (4), and one known ceramide (5). Their structures were elucidated by comprehensive spectroscopic analyses, including NMR and HRESIMS, and by comparison with previous data for related compounds in the literature. The cytotoxic activities of the isolated compounds were assessed using MTT colorimetric assay against MCF-7 and OVK-18 cancer cell lines.
AB - Further chemical study of the crude extract of the soft coral Heteroxenia fuscescens (Fam., Xeniidea), led to isolation of two new sterols, Heterofuscesterols A (1) and B (2), a sterol isolated for the first time from natural sources, 3β,5α,6β-trihydroxyandrosta-17-one (3), along with one new hydroperoxy sesquiterpene, Heterofusceterpene A (4), and one known ceramide (5). Their structures were elucidated by comprehensive spectroscopic analyses, including NMR and HRESIMS, and by comparison with previous data for related compounds in the literature. The cytotoxic activities of the isolated compounds were assessed using MTT colorimetric assay against MCF-7 and OVK-18 cancer cell lines.
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U2 - 10.1016/j.phytol.2020.02.006
DO - 10.1016/j.phytol.2020.02.006
M3 - Article
AN - SCOPUS:85079858769
VL - 36
SP - 156
EP - 161
JO - Phytochemistry Letters
JF - Phytochemistry Letters
SN - 1874-3900
ER -
