Isolation of PSD-Zip45, a novel Homer/vesl family protein containing leucine zipper motifs, from rat brain

Jie Sun, Satoko Tadokoro, Takanobu Imanaka, Seiko D. Murakami, Mako Nakamura, Kouji Kashiwada, Jiae Ko, Wataru Nishida, Kenji Sobue

研究成果: ジャーナルへの寄稿記事

61 引用 (Scopus)

抄録

Using monoclonal antibody against the 45 kDa postsynaptic density protein, we isolated a novel isoform of Homer/vesl. The NH2-terminal region containing a PDZ domain of this protein is identical to that of Homer/vesl, and the COOH-terminal region containing unique leucine zippers shows self-multimerization. We named this protein PSD-Zip45. In addition to specific binding of PSD-Zip45 mediated by a PDZ domain to the metabotropic glutamate receptors 1α or 5, the distribution of PSD-Zip45 transcripts is highly consistent with that of metabotropic glutamate receptor transcripts. The PSD-Zip45 is, therefore, the first candidate as receptor anchoring proteins containing leucine zipper motifs in the central nervous system. Copyright (C) 1998 Federation of European Biochemical Societies.

元の言語英語
ページ(範囲)304-308
ページ数5
ジャーナルFEBS Letters
437
発行部数3
DOI
出版物ステータス出版済み - 10 23 1998
外部発表Yes

Fingerprint

Leucine Zippers
PDZ Domains
Rats
Brain
Metabotropic Glutamate Receptors
Proteins
Neurology
Protein Isoforms
Central Nervous System
Monoclonal Antibodies

All Science Journal Classification (ASJC) codes

  • Biophysics
  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology

これを引用

Isolation of PSD-Zip45, a novel Homer/vesl family protein containing leucine zipper motifs, from rat brain. / Sun, Jie; Tadokoro, Satoko; Imanaka, Takanobu; D. Murakami, Seiko; Nakamura, Mako; Kashiwada, Kouji; Ko, Jiae; Nishida, Wataru; Sobue, Kenji.

:: FEBS Letters, 巻 437, 番号 3, 23.10.1998, p. 304-308.

研究成果: ジャーナルへの寄稿記事

Sun, J, Tadokoro, S, Imanaka, T, D. Murakami, S, Nakamura, M, Kashiwada, K, Ko, J, Nishida, W & Sobue, K 1998, 'Isolation of PSD-Zip45, a novel Homer/vesl family protein containing leucine zipper motifs, from rat brain', FEBS Letters, 巻. 437, 番号 3, pp. 304-308. https://doi.org/10.1016/S0014-5793(98)01256-3
Sun, Jie ; Tadokoro, Satoko ; Imanaka, Takanobu ; D. Murakami, Seiko ; Nakamura, Mako ; Kashiwada, Kouji ; Ko, Jiae ; Nishida, Wataru ; Sobue, Kenji. / Isolation of PSD-Zip45, a novel Homer/vesl family protein containing leucine zipper motifs, from rat brain. :: FEBS Letters. 1998 ; 巻 437, 番号 3. pp. 304-308.
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abstract = "Using monoclonal antibody against the 45 kDa postsynaptic density protein, we isolated a novel isoform of Homer/vesl. The NH2-terminal region containing a PDZ domain of this protein is identical to that of Homer/vesl, and the COOH-terminal region containing unique leucine zippers shows self-multimerization. We named this protein PSD-Zip45. In addition to specific binding of PSD-Zip45 mediated by a PDZ domain to the metabotropic glutamate receptors 1α or 5, the distribution of PSD-Zip45 transcripts is highly consistent with that of metabotropic glutamate receptor transcripts. The PSD-Zip45 is, therefore, the first candidate as receptor anchoring proteins containing leucine zipper motifs in the central nervous system. Copyright (C) 1998 Federation of European Biochemical Societies.",
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AU - D. Murakami, Seiko

AU - Nakamura, Mako

AU - Kashiwada, Kouji

AU - Ko, Jiae

AU - Nishida, Wataru

AU - Sobue, Kenji

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