Ivy Cells: A Population of Nitric-Oxide-Producing, Slow-Spiking GABAergic Neurons and Their Involvement in Hippocampal Network Activity

Pablo Fuentealba, Rahima Begum, Marco Capogna, Shozo Jinno, László F. Márton, Jozsef Csicsvari, Alex Thomson, Peter Somogyi, Thomas Klausberger

研究成果: Contribution to journalArticle査読

160 被引用数 (Scopus)

抄録

In the cerebral cortex, GABAergic interneurons are often regarded as fast-spiking cells. We have identified a type of slow-spiking interneuron that offers distinct contributions to network activity. "Ivy" cells, named after their dense and fine axons innervating mostly basal and oblique pyramidal cell dendrites, are more numerous than the parvalbumin-expressing basket, bistratified, or axo-axonic cells. Ivy cells express nitric oxide synthase, neuropeptide Y, and high levels of GABAA receptor α1 subunit; they discharge at a low frequency with wide spikes in vivo, yet are distinctively phase-locked to behaviorally relevant network rhythms including theta, gamma, and ripple oscillations. Paired recordings in vitro showed that Ivy cells receive depressing EPSPs from pyramidal cells, which in turn receive slowly rising and decaying inhibitory input from Ivy cells. In contrast to fast-spiking interneurons operating with millisecond precision, the highly abundant Ivy cells express presynaptically acting neuromodulators and regulate the excitability of pyramidal cell dendrites through slowly rising and decaying GABAergic inputs.

本文言語英語
ページ(範囲)917-929
ページ数13
ジャーナルNeuron
57
6
DOI
出版ステータス出版済み - 3 27 2008

All Science Journal Classification (ASJC) codes

  • 神経科学(全般)

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