Japanese clinical practice guidelines for sacrococcygeal teratoma, 2017

Shigehisa Fumino, Tatsuro Tajiri, Noriaki Usui, Masanori Tamura, Haruhiko Sago, Shigeru Ono, Shunsuke Nosaka, Akihiro Yoneda, Ryota Souzaki, Mayumi Higashi, Kohei Sakai, Ken Takahashi, Takahiro Sugiura, Tomoaki Taguchi

研究成果: Contribution to journalArticle査読

4 被引用数 (Scopus)


Background: Sacrococcygeal teratoma (SCT) is the most common extragonadal germ cell tumor in neonates and infants. Although most cases of infantile SCT are benign tumors by nature, some develop into extremely large lesions, leading to massive bleeding, high-output heart failure, disseminated intravascular coagulation, and even fatal outcomes during the neonatal period. In addition, some patients may present with tumor recurrence, malignant transformation, long-term sequelae (including bladder and bowel dysfunction) and lower leg palsy during the long-term follow up. SCT, however, is very rare, and there are few opportunities to encounter this disease, therefore general physicians without expert credentials currently lack information relevant to clinical practice. For this reason, the research project committee has compiled guidelines concerning SCT. Methods: The purpose of these guidelines was to share information concerning the treatment and follow up of infantile SCT. The guidelines were developed using the methodologies in the Medical Information Network Distribution System. A comprehensive search of the English- and Japanese-language articles in PubMed and Ichu-Shi Web identified only case reports or case series, and the recommendations were developed through a process of informal consensus. Results: The clinical questions addressed the risk factors, the efficacy of cesarean section, the initial devascularization of tumor feeding vessels, interventional radiology, recommended clinical studies for follow up and possible long-term complications. Conclusions: These are the first guidelines for SCT to be established in Japan, and they may have huge clinical value and significance in terms of developing therapeutic strategies and follow up, potentially contributing to the improvement of the prognosis and quality of life of SCT patients.

ジャーナルPediatrics International
出版ステータス出版済み - 7 2019

All Science Journal Classification (ASJC) codes

  • Pediatrics, Perinatology, and Child Health

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