JB special review - Wnt signaling: Biological functions and its implications in diseases: Arl4c is a key regulator of tubulogenesis and tumourigenesis as a target gene of Wnt - β-catenin and growth factor - Ras signalling

Shinji Matsumoto, Shinsuke Fujii, Akira Kikuchi

研究成果: Contribution to journalReview article査読

17 被引用数 (Scopus)

抄録

Epithelial tubular morphogenesis (tubulogenesis) is a fundamental morphogenetic process of many epithelial organs. In this developmental process, epithelial cells migrate, proliferate, polarize and differentiate towards surrounding mesenchymal tissue to form tubule structures. Although epithelial tissue structures are basically stable in the postnatal period, epithelial cells regain highly proliferative and invasive potentials within mesenchymal tissue during tumour formation (tumourigenesis). Therefore, there must be a common molecular basis orchestrating the cellular behaviours involved in both tubulogenesis and tumourigenesis. ADP-ribosylation factor (Arf)-like protein 4c (Arl4c), which belongs to the small GTP-binding protein family, is expressed by the simultaneous activation of Wnt - β-catenin and growth factor - Ras-mitogen-activated protein kinase signalling, was identified as an essential regulator of tubulogenesis. Arl4c expression was also involved in the tumour formation of colorectal and lung cancers. In this review, we focus on Arl4c as a novel Wnt signal target molecule that links epithelial tubulogenesis to tumourigenesis.

本文言語英語
ページ(範囲)27-35
ページ数9
ジャーナルJournal of biochemistry
161
1
DOI
出版ステータス出版済み - 1 2017

All Science Journal Classification (ASJC) codes

  • 生化学
  • 分子生物学

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