Kamishoyosan reduces conditioned fear-induced freezing behavior in socially isolated ovariectomized rats

Nobuaki Egashira, Hikari Iba, Haruna Kuwano, Rikako Kawanaka, Masaki Nagao, Hiroshi Moriyama, Takuya Watanabe, Kaori Kubota, Shutaro Katsurabayashi, Katsunori Iwasaki

研究成果: ジャーナルへの寄稿記事

4 引用 (Scopus)

抄録

In the present study, we investigated the effect of kamishoyosan (KSS) on conditioned fear-induced freezing in ovariectomized (OVX) rats. Socially isolated OVX rats showed the longest freezing time among the following four groups: group-housed sham-operated (Sham), isolated Sham, group-housed OVX, and isolated OVX rats. Repeated oral administration of KSS (30–300 mg/kg) reduced conditioned fear-induced freezing in socially isolated OVX rats. The reduction of freezing by KSS was reversed by flumazenil (3 mg/kg) and bicuculline (3 mg/kg). These findings suggest that the GABAA-benzodiazepine receptor complex is involved in the anxiolytic effect of KSS in socially isolated OVX rats.

元の言語英語
ページ(範囲)279-283
ページ数5
ジャーナルJournal of Pharmacological Sciences
131
発行部数4
DOI
出版物ステータス出版済み - 8 1 2016

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Freezing
Fear
GABA-A Receptors
Flumazenil
Bicuculline
Anti-Anxiety Agents
Oral Administration

All Science Journal Classification (ASJC) codes

  • Molecular Medicine
  • Pharmacology

これを引用

Kamishoyosan reduces conditioned fear-induced freezing behavior in socially isolated ovariectomized rats. / Egashira, Nobuaki; Iba, Hikari; Kuwano, Haruna; Kawanaka, Rikako; Nagao, Masaki; Moriyama, Hiroshi; Watanabe, Takuya; Kubota, Kaori; Katsurabayashi, Shutaro; Iwasaki, Katsunori.

:: Journal of Pharmacological Sciences, 巻 131, 番号 4, 01.08.2016, p. 279-283.

研究成果: ジャーナルへの寄稿記事

Egashira, N, Iba, H, Kuwano, H, Kawanaka, R, Nagao, M, Moriyama, H, Watanabe, T, Kubota, K, Katsurabayashi, S & Iwasaki, K 2016, 'Kamishoyosan reduces conditioned fear-induced freezing behavior in socially isolated ovariectomized rats', Journal of Pharmacological Sciences, 巻. 131, 番号 4, pp. 279-283. https://doi.org/10.1016/j.jphs.2016.07.007
Egashira, Nobuaki ; Iba, Hikari ; Kuwano, Haruna ; Kawanaka, Rikako ; Nagao, Masaki ; Moriyama, Hiroshi ; Watanabe, Takuya ; Kubota, Kaori ; Katsurabayashi, Shutaro ; Iwasaki, Katsunori. / Kamishoyosan reduces conditioned fear-induced freezing behavior in socially isolated ovariectomized rats. :: Journal of Pharmacological Sciences. 2016 ; 巻 131, 番号 4. pp. 279-283.
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abstract = "In the present study, we investigated the effect of kamishoyosan (KSS) on conditioned fear-induced freezing in ovariectomized (OVX) rats. Socially isolated OVX rats showed the longest freezing time among the following four groups: group-housed sham-operated (Sham), isolated Sham, group-housed OVX, and isolated OVX rats. Repeated oral administration of KSS (30–300 mg/kg) reduced conditioned fear-induced freezing in socially isolated OVX rats. The reduction of freezing by KSS was reversed by flumazenil (3 mg/kg) and bicuculline (3 mg/kg). These findings suggest that the GABAA-benzodiazepine receptor complex is involved in the anxiolytic effect of KSS in socially isolated OVX rats.",
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AU - Iba, Hikari

AU - Kuwano, Haruna

AU - Kawanaka, Rikako

AU - Nagao, Masaki

AU - Moriyama, Hiroshi

AU - Watanabe, Takuya

AU - Kubota, Kaori

AU - Katsurabayashi, Shutaro

AU - Iwasaki, Katsunori

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