Knockout Mouse Models Provide Insight into the Biological Functions of CRL1 Components

Tadashi Nakagawa, Keiko Nakayama, Keiichi I. Nakayama

研究成果: 著書/レポートタイプへの貢献

抜粋

The CRL1 complex, also known as the SCF complex, is a ubiquitin ligase that in mammals consists of an adaptor protein (SKP1), a scaffold protein (CUL1), a RING finger protein (RBX1, also known as ROC1), and one of about 70 F-box proteins. Given that the F-box proteins determine the substrate specificity of the CRL1 complex, the variety of these proteins allows the generation of a large number of ubiquitin ligases that promote the degradation or regulate the function of many substrate proteins and thereby control numerous key cellular processes. The physiological and pathological functions of these many CRL1 ubiquitin ligases have been studied by the generation and characterization of knockout mouse models that lack specific CRL1 components. In this chapter, we provide a comprehensive overview of these mouse models and discuss the role of each CRL1 component in mouse physiology and pathology.

元の言語英語
ホスト出版物のタイトルAdvances in Experimental Medicine and Biology
出版者Springer
ページ147-171
ページ数25
DOI
出版物ステータス出版済み - 1 1 2020

出版物シリーズ

名前Advances in Experimental Medicine and Biology
1217
ISSN(印刷物)0065-2598
ISSN(電子版)2214-8019

    フィンガープリント

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)

これを引用

Nakagawa, T., Nakayama, K., & Nakayama, K. I. (2020). Knockout Mouse Models Provide Insight into the Biological Functions of CRL1 Components. : Advances in Experimental Medicine and Biology (pp. 147-171). (Advances in Experimental Medicine and Biology; 巻数 1217). Springer. https://doi.org/10.1007/978-981-15-1025-0_10