抄録
Koji, which is manufactured by proliferating non-pathogenic fungus Aspergillus oryzae on steamed rice, is the base for Japanese traditional fermented foods. We have revealed that koji and related Japanese fermented foods and drinks such as amazake, shio-koji, unfiltered sake and miso contain abundant glycosylceramide. Here, we report that feeding of koji glycosylceramide to obese mice alters the cholesterol metabolism . Liver cholesterol was significantly decreased in obese mice fed with koji glycosylceramide. We hypothesized that their liver cholesterol was decreased because it was converted to bile acids. Consistent with the hypothesis, many bile acids were increased in the cecum and feces of obese mice fed with koji glycosylceramide. Expressions of CYP7A1 and ABCG8 involved in the metabolism of cholesterol were significantly increased in the liver of mice fed with koji glycosylceramide. Therefore, it was considered that koji glycosylceramide affects the cholesterol metabolism in obese mice.
| 元の言語 | 英語 |
|---|---|
| ページ（範囲） | 1514-1522 |
| ページ数 | 9 |
| ジャーナル | Bioscience, Biotechnology and Biochemistry |
| 巻 | 83 |
| 発行部数 | 8 |
| DOI | |
| 出版物ステータス | 出版済み - 1 1 2019 |
Fingerprint
All Science Journal Classification (ASJC) codes
- Biotechnology
- Analytical Chemistry
- Biochemistry
- Applied Microbiology and Biotechnology
- Molecular Biology
- Organic Chemistry
これを引用
Koji glycosylceramide commonly contained in Japanese traditional fermented foods alters cholesterol metabolism in obese mice. / Hamajima, Hiroshi; Tanaka, Masaru; Miyagawa, Miyuki; Sakamoto, Mayuko; Nakamura, Tsuyoshi; Yanagita, Teruyoshi; Nishimukai, Megumi; Mitsutake, Susumu; Nakayama, Jiro; Nagao, Koji; Kitagaki, Hiroshi.
：: Bioscience, Biotechnology and Biochemistry, 巻 83, 番号 8, 01.01.2019, p. 1514-1522.研究成果: ジャーナルへの寄稿 › 記事
}
TY - JOUR
T1 - Koji glycosylceramide commonly contained in Japanese traditional fermented foods alters cholesterol metabolism in obese mice
AU - Hamajima, Hiroshi
AU - Tanaka, Masaru
AU - Miyagawa, Miyuki
AU - Sakamoto, Mayuko
AU - Nakamura, Tsuyoshi
AU - Yanagita, Teruyoshi
AU - Nishimukai, Megumi
AU - Mitsutake, Susumu
AU - Nakayama, Jiro
AU - Nagao, Koji
AU - Kitagaki, Hiroshi
PY - 2019/1/1
Y1 - 2019/1/1
N2 - Koji, which is manufactured by proliferating non-pathogenic fungus Aspergillus oryzae on steamed rice, is the base for Japanese traditional fermented foods. We have revealed that koji and related Japanese fermented foods and drinks such as amazake, shio-koji, unfiltered sake and miso contain abundant glycosylceramide. Here, we report that feeding of koji glycosylceramide to obese mice alters the cholesterol metabolism . Liver cholesterol was significantly decreased in obese mice fed with koji glycosylceramide. We hypothesized that their liver cholesterol was decreased because it was converted to bile acids. Consistent with the hypothesis, many bile acids were increased in the cecum and feces of obese mice fed with koji glycosylceramide. Expressions of CYP7A1 and ABCG8 involved in the metabolism of cholesterol were significantly increased in the liver of mice fed with koji glycosylceramide. Therefore, it was considered that koji glycosylceramide affects the cholesterol metabolism in obese mice.
AB - Koji, which is manufactured by proliferating non-pathogenic fungus Aspergillus oryzae on steamed rice, is the base for Japanese traditional fermented foods. We have revealed that koji and related Japanese fermented foods and drinks such as amazake, shio-koji, unfiltered sake and miso contain abundant glycosylceramide. Here, we report that feeding of koji glycosylceramide to obese mice alters the cholesterol metabolism . Liver cholesterol was significantly decreased in obese mice fed with koji glycosylceramide. We hypothesized that their liver cholesterol was decreased because it was converted to bile acids. Consistent with the hypothesis, many bile acids were increased in the cecum and feces of obese mice fed with koji glycosylceramide. Expressions of CYP7A1 and ABCG8 involved in the metabolism of cholesterol were significantly increased in the liver of mice fed with koji glycosylceramide. Therefore, it was considered that koji glycosylceramide affects the cholesterol metabolism in obese mice.
UR - http://www.scopus.com/inward/record.url?scp=85068619596&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85068619596&partnerID=8YFLogxK
U2 - 10.1080/09168451.2018.1562877
DO - 10.1080/09168451.2018.1562877
M3 - Article
VL - 83
SP - 1514
EP - 1522
JO - Bioscience, Biotechnology and Biochemistry
JF - Bioscience, Biotechnology and Biochemistry
SN - 0916-8451
IS - 8
ER -