TY - JOUR
T1 - Koji glycosylceramide commonly contained in Japanese traditional fermented foods alters cholesterol metabolism in obese mice
AU - Hamajima, Hiroshi
AU - Tanaka, Masaru
AU - Miyagawa, Miyuki
AU - Sakamoto, Mayuko
AU - Nakamura, Tsuyoshi
AU - Yanagita, Teruyoshi
AU - Nishimukai, Megumi
AU - Mitsutake, Susumu
AU - Nakayama, Jiro
AU - Nagao, Koji
AU - Kitagaki, Hiroshi
N1 - Funding Information:
Part of this study was financially supported by Japan Association for Techno-innovation in Agriculture, Forestry and Fisheries [grant number 26056A].
PY - 2019
Y1 - 2019
N2 - Koji, which is manufactured by proliferating non-pathogenic fungus Aspergillus oryzae on steamed rice, is the base for Japanese traditional fermented foods. We have revealed that koji and related Japanese fermented foods and drinks such as amazake, shio-koji, unfiltered sake and miso contain abundant glycosylceramide. Here, we report that feeding of koji glycosylceramide to obese mice alters the cholesterol metabolism . Liver cholesterol was significantly decreased in obese mice fed with koji glycosylceramide. We hypothesized that their liver cholesterol was decreased because it was converted to bile acids. Consistent with the hypothesis, many bile acids were increased in the cecum and feces of obese mice fed with koji glycosylceramide. Expressions of CYP7A1 and ABCG8 involved in the metabolism of cholesterol were significantly increased in the liver of mice fed with koji glycosylceramide. Therefore, it was considered that koji glycosylceramide affects the cholesterol metabolism in obese mice.
AB - Koji, which is manufactured by proliferating non-pathogenic fungus Aspergillus oryzae on steamed rice, is the base for Japanese traditional fermented foods. We have revealed that koji and related Japanese fermented foods and drinks such as amazake, shio-koji, unfiltered sake and miso contain abundant glycosylceramide. Here, we report that feeding of koji glycosylceramide to obese mice alters the cholesterol metabolism . Liver cholesterol was significantly decreased in obese mice fed with koji glycosylceramide. We hypothesized that their liver cholesterol was decreased because it was converted to bile acids. Consistent with the hypothesis, many bile acids were increased in the cecum and feces of obese mice fed with koji glycosylceramide. Expressions of CYP7A1 and ABCG8 involved in the metabolism of cholesterol were significantly increased in the liver of mice fed with koji glycosylceramide. Therefore, it was considered that koji glycosylceramide affects the cholesterol metabolism in obese mice.
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U2 - 10.1080/09168451.2018.1562877
DO - 10.1080/09168451.2018.1562877
M3 - Article
C2 - 30595103
AN - SCOPUS:85068619596
VL - 83
SP - 1514
EP - 1522
JO - Bioscience, Biotechnology and Biochemistry
JF - Bioscience, Biotechnology and Biochemistry
SN - 0916-8451
IS - 8
ER -