L-DOPA attenuates hyperactivity of Roborovskii hamsters

Yusuke Kabuki, Kazutaka Shigemi, Kousuke Hamasu, Mitsuhiro Furuse

研究成果: Contribution to journalArticle査読

8 被引用数 (Scopus)

抄録

The Roborovskii hamster (Phodopus roborovskii) has been shown to have high locomotor activity (hyperactivity) and low dopamine concentrations in the brain. We hypothesized that low brain dopamine concentrations play a role in the pathogenesis of hyperactivity. In this study, therefore, we investigated the effects of L-DOPA (L-3,4-dihydroxyphenylalanine), the precursor of dopamine, on the locomotor activity of Roborovskii hamster to verify the above hypothesis. An open field test was employed to measure the locomotor activity. Administration of L-DOPA dose-dependently decreased locomotor activity including distance of path and time spent moving. L-DOPA increased the brain concentration of dopamine and its metabolite 3,4-dihydroxyphenylacetic acid. Concurrently, L-DOPA caused increase of norepinephrine, decrease of serotonin, and atypical alteration of their metabolite concentrations. These findings mainly suggest that in Roborovskii hamsters, a low level of brain dopamine neurotransmission is one of the reasons for hyperactivity, and hyperactivity can be attenuated by L-DOPA.

本文言語英語
ページ(範囲)260-264
ページ数5
ジャーナルBehavioural Pharmacology
20
3
DOI
出版ステータス出版済み - 5 1 2009

All Science Journal Classification (ASJC) codes

  • 薬理学
  • 精神医学および精神衛生

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