Glial cells support the survival and development of central neurons through the supply of trophic factors. Here we demonstrate that L-serine (L-Ser) and glycine (Gly) also are glia-derived trophic factors. These amino acids are released by astroglial cells and promote the survival, dendritogenesis, and electrophysiological development of cultured cerebellar Purkinje neurons. Although L-Ser and Gly are generally classified as nonessential amino acids, 3-phosphoglycerate dehydrogenase (3PGDH), a key enzyme for their biosynthesis, is not expressed in Purkinje neurons. By contrast, the Bergman glia, a native astroglia in the cerebellar cortex, highly expresses 3PGDH. These data suggest that L-Ser and Gly mediate the trophic actions of glial cells on Purkinje neurons.
|ジャーナル||Proceedings of the National Academy of Sciences of the United States of America|
|出版ステータス||出版済み - 10 10 2000|
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