Laboratory and clinical evaluation of doripenem in deep-seated skin infection

Jirô Arata, Shinichi Watanabe, Yoshiki Miyachi, Masutaka Furue

研究成果: ジャーナルへの寄稿学術誌査読

1 被引用数 (Scopus)

抄録

We conducted a multicenter clinical trial of doripenem (DRPM), a new carbapenem for injection, to examine its skin penetration and its clinical efficacy and safety in deep-seated skin infections. The concentration in skin tissue was 2.29-3.15 μg/g and in plasma 6.48-18.1 μg/mL 30-70 minutes after a single i.v. injection of 250 mg of DRPM. The ratio of skin concentration to plasma concentration was 15.7-36.9%. The minimum inhibitory concentration (MIC) against two clinical isolates of Staphylococcus aureus was 0.05 μg/mL. DRPM was administered to 22 patients at a dose of 250 mg or 500 mg twice a day for 5-8 days. Overall clinical efficacy was 100% (19/19). Cases by diagnosis consisted of 10 of cellulitis, 3 of erysipelas, 3 of lymphangitis, 1 of lymphadenitis and 2 of carbuncle. The bacteriological response was 85.0% (17/20). Adverse reactions were observed in 13.6% (3/22) and abnormal laboratory findings in 36.4% (8/22). One developed pseudomembranous colitis after DRPM treatment followed by oral cefcapene pivoxil, and the causal relationship to the treatment with DRPM could not be ruled out. This adverse reaction disappeared rapidly after vancomycin administration. These results suggest that DRPM is a useful antibacterial agent for deep-seated skin infection.

本文言語英語
ページ(範囲)303-312
ページ数10
ジャーナルJapanese Journal of Chemotherapy
53
SUPPL. 1
出版ステータス出版済み - 7月 2005

!!!All Science Journal Classification (ASJC) codes

  • 薬理学
  • 薬理学(医学)

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